Literature DB >> 25740812

Patient-relevant endpoints in inflammatory bowel diseases--have changes occurred in Germany over the past twelve years?

Andreas Stallmach1, Ulf Dennler2, Ursula Marschall3, Carsten Schmidt4.   

Abstract

BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) are gaining increasing medical as well as economic significance. Improving medical treatment options can have a positive effect on number of hospitalized patients, necessary operations and the inability to work.
METHODS: To understand patient-relevant endpoints in IBDs, the data for 2000-12 published by the Federal Statistical Office and the data for 2012 according to Article 21 of the Hospital Reimbursement Act in Germany were assessed. In addition, data records held by a public health insurance company on the medication of IBD patients were evaluated.
RESULTS: During 2000-12, the number of hospitalized IBD patients (ICD 10 K50, K51) rose from 38533 to 43452 (+12.7%). The necessity of surgical intervention increased during the period under review. The number of people unable to work increased differently for Crohn's disease (CD) and ulcerative colitis (UC), by 2.1 and 9.5%, respectively. Entry of persons into the statutory pension insurance system did not decline from 2000 to 2012. The number of potential years of life lost (PYLL) in patients with IBD also remained constant during the period under review (2017 in 2000-02 versus 2011 in 2010-012). From 2009 to 2013 the percentage of patients treated with an anti-TNF-antibodies rose (2009, 4.3% for CD and 1.4% for UC; 2013, 8.4% for CD and 3.2% for UC).
CONCLUSIONS: An improvement in patient-relevant endpoints was not observed between 2000 and 2012 in IBD patients in Germany. Improvements can only be achieved through structured and interdisciplinary treatment concepts involving all healthcare providers.
Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  Inflammatory bowel disease; antibodies; immunosuppression; morbidity; mortality; outcome

Mesh:

Substances:

Year:  2015        PMID: 25740812     DOI: 10.1093/ecco-jcc/jjv041

Source DB:  PubMed          Journal:  J Crohns Colitis        ISSN: 1873-9946            Impact factor:   9.071


  3 in total

1.  Surgical Rates for Crohn's Disease are Decreasing: A Population-Based Time Trend Analysis and Validation Study.

Authors:  Christopher Ma; Gordon W Moran; Eric I Benchimol; Laura E Targownik; Steven J Heitman; James N Hubbard; Cynthia H Seow; Kerri L Novak; Subrata Ghosh; Remo Panaccione; Gilaad G Kaplan
Journal:  Am J Gastroenterol       Date:  2017-10-31       Impact factor: 10.864

2.  Patient-relevant outcomes: what are we talking about? A scoping review to improve conceptual clarity.

Authors:  Christine Kersting; Malte Kneer; Anne Barzel
Journal:  BMC Health Serv Res       Date:  2020-06-29       Impact factor: 2.655

3.  The Impact of Inflammatory Bowel Disease in Canada 2018: Indirect Costs of IBD Care.

Authors:  M Ellen Kuenzig; Lawrence Lee; Wael El-Matary; Adam V Weizman; Eric I Benchimol; Gilaad G Kaplan; Geoffrey C Nguyen; Charles N Bernstein; Alain Bitton; Kate Lee; Jane Cooke-Lauder; Sanjay K Murthy
Journal:  J Can Assoc Gastroenterol       Date:  2018-11-02
  3 in total

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