Kadri Andre1, Olli Kampman2, Ari Illi3, Merja Viikki4, Eija Setälä-Soikkeli5, Nina Mononen6, Terho Lehtimäki7, Susann Haraldsson8, Pasi A Koivisto9, Esa Leinonen10. 1. a Kadri Andre M.D., School of Medicine, University of Tampere , Finland. 2. b Olli Kampman M.D., Ph.D., School of Medicine, University of Tampere , Tampere , and Department of Psychiatry , Seinäjoki Hospital District , Seinäjoki , Finland. 3. c Ari Illi M.D., Ph.D., School of Medicine, University of Tampere , Finland. 4. d Merja Viikki, M.D., Ph.D., School of Medicine, University of Tampere , Tampere , and Tampere City Mental Health Care Centre , Tampere , Finland. 5. e Eija Setälä-Soikkeli, M.D., School of Medicine, University of Tampere , Tampere , and Department of Psychiatry , Kanta-Häme Hospital District , Hämeenlinna , Finland. 6. f Nina Mononen, Ph.D., School of Medicine, University of Tampere; Department of Clinical Chemistry , Pirkanmaa Hospital District; and Fimlab Laboratories , Tampere , Finland. 7. g Terho Lehtimäki M.D., Ph.D., School of Medicine, University of Tampere , Tampere , Department of Clinical Chemistry , Pirkanmaa Hospital District, and Fimlab Laboratories , Tampere , Finland. 8. h Susann Haraldsson, Department of Medical Biosciences , Umeå University , Umeå , Sweden. 9. i Pasi A. Koivisto, Department of Neurology , Seinäjoki Hospital District , Seinäjoki , Finland. 10. j Esa Leinonen M.D., Ph.D., School of Medicine, University of Tampere , Tampere , and Department of Psychiatry , Tampere University Hospital , Tampere , Finland.
Abstract
BACKGROUND: The genetic variations in norepinephrine transporter (NET) and serotonin transporter (SERT) genes have been associated with personality traits, several psychiatric disorders and the efficacy of antidepressant treatment. AIMS: We investigated the separate effects and possible interactions between NET T-182C (rs2242446) and SERT 5-HTTLPR (rs4795541) polymorphisms on selective serotonin reuptake inhibitors (SSRI) treatment response and temperamental traits assessed by the Temperament and Character Inventory (TCI) in a clinical sample of subjects with major depressive disorder (MDD). METHODS: Our sample of 97 patients with major depression completed the 107-item TCI temperament questionnaire (version IX) at the initial assessment of the study and after 6 weeks of follow-up. All subjects received selective SSRI medications. Temperament dimension scores at baseline ( 1 ) and endpoint ( 2 ) during antidepressant treatment were analyzed between NET and SERT genotypes. RESULTS: SS-genotype of 5-HTTLPR was associated with higher baseline Persistence scores than SL- or LL-genotype. A corresponding but weaker association was found at endpoint. No differences were found between 5-HTTLPR genotypes and other temperament dimensions and 5-HTTLPR genotypes had no effect on treatment response. CONCLUSIONS: Our results suggest that the SS-genotype of 5-HTTLPR is associated with Persistence scores in patients with MDD. Higher Persistence could be viewed as a negative trait when recovering from stress and its association with short and "weaker" S-allele may be related to less efficient serotonin neurotransmission, possibly resulting in less effective coping strategies on a behavioral level.
BACKGROUND: The genetic variations in norepinephrine transporter (NET) and serotonin transporter (SERT) genes have been associated with personality traits, several psychiatric disorders and the efficacy of antidepressant treatment. AIMS: We investigated the separate effects and possible interactions between NET T-182C (rs2242446) and SERT 5-HTTLPR (rs4795541) polymorphisms on selective serotonin reuptake inhibitors (SSRI) treatment response and temperamental traits assessed by the Temperament and Character Inventory (TCI) in a clinical sample of subjects with major depressive disorder (MDD). METHODS: Our sample of 97 patients with major depression completed the 107-item TCI temperament questionnaire (version IX) at the initial assessment of the study and after 6 weeks of follow-up. All subjects received selective SSRI medications. Temperament dimension scores at baseline ( 1 ) and endpoint ( 2 ) during antidepressant treatment were analyzed between NET and SERT genotypes. RESULTS: SS-genotype of 5-HTTLPR was associated with higher baseline Persistence scores than SL- or LL-genotype. A corresponding but weaker association was found at endpoint. No differences were found between 5-HTTLPR genotypes and other temperament dimensions and 5-HTTLPR genotypes had no effect on treatment response. CONCLUSIONS: Our results suggest that the SS-genotype of 5-HTTLPR is associated with Persistence scores in patients with MDD. Higher Persistence could be viewed as a negative trait when recovering from stress and its association with short and "weaker" S-allele may be related to less efficient serotonin neurotransmission, possibly resulting in less effective coping strategies on a behavioral level.
Authors: Jasmin N Beaver; Brady L Weber; Matthew T Ford; Anna E Anello; Sarah K Kassis; T Lee Gilman Journal: Cells Date: 2022-06-09 Impact factor: 7.666