Jason Y Y Wong1, Shona C Fang, Rachel Grashow, Tianteng Fan, David C Christiani. 1. From the Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine (Dr Wong); Veterans' Affairs Palo Alto Health Care System (Dr Wong), Calif; New England Research Institute (Dr Fang), Watertown; Department of Environmental Health (Drs Fang, Grashow, Fan, and Christiani), Harvard School of Public Health; Department of Medicine (Dr Christiani), Harvard Medical School-Massachusetts General Hospital, Boston; Adheris Health (Dr Fan), Burlington, Mass.
Abstract
BACKGROUND: The objective of this study was to evaluate the relationship between cumulative occupational exposure to various metals and arterial compliance in welders. METHODS: The observational follow-up study consisted of 25 subjects. Levels of nickel (Ni), lead, cadmium, manganese, and arsenic from toenails were assessed using mass spectrometry. Arterial compliance as reflected by augmentation index (AIx) was measured using SphygmoCor Px Pulse Wave Analysis System. Linear regression models were used to assess the associations. RESULTS: For every 1 unit increase in log-transformed toenail Ni, there was a statistically significant 5.68 (95% confidence interval, 1.38 to 9.98; P = 0.01) unit increase in AIx. No significant associations were found between AIx and lead, cadmium, manganese, and arsenic. CONCLUSIONS: Cumulative Ni exposure is associated with increased arterial stiffness in welders and may increase risk of adverse cardiovascular outcomes.
BACKGROUND: The objective of this study was to evaluate the relationship between cumulative occupational exposure to various <span class="Chemical">metals and arterial compliance in welders. METHODS: The observational follow-up study consisted of 25 subjects. Levels of nickel (Ni), lead, cadmium, manganese, and arsenic from toenails were assessed using mass spectrometry. Arterial compliance as reflected by augmentation index (AIx) was measured using SphygmoCor Px Pulse Wave Analysis System. Linear regression models were used to assess the associations. RESULTS: For every 1 unit increase in log-transformed toenail Ni, there was a statistically significant 5.68 (95% confidence interval, 1.38 to 9.98; P = 0.01) unit increase in AIx. No significant associations were found between AIx and lead, cadmium, manganese, and arsenic. CONCLUSIONS: Cumulative Ni exposure is associated with increased arterial stiffness in welders and may increase risk of adverse cardiovascular outcomes.
Authors: Ming Li; Min Zhang; Luping Huang; Jianxin Zhou; Hean Zhuang; James T Taylor; Brian M Keyser; Richard M Whitehurst Journal: Pediatr Res Date: 2005-02-04 Impact factor: 3.756
Authors: S P Glasser; D K Arnett; G E McVeigh; S M Finkelstein; A K Bank; D J Morgan; J N Cohn Journal: J Clin Pharmacol Date: 1998-03 Impact factor: 3.126
Authors: Carmel M McEniery; Sharon Wallace; Kaisa Maki-Petaja; Barry McDonnell; James E Sharman; Christopher Retallick; Stanley S Franklin; Morris J Brown; R Catherine Lloyd; John R Cockcroft; Ian B Wilkinson Journal: Hypertension Date: 2005-07 Impact factor: 10.190
Authors: Shona C Fang; Ellen A Eisen; Jennifer M Cavallari; Murray A Mittleman; David C Christiani Journal: Epidemiology Date: 2008-03 Impact factor: 4.822
Authors: Shona C Fang; Jennifer M Cavallari; Ellen A Eisen; Jiu-Chiuan Chen; Murray A Mittleman; David C Christiani Journal: Am J Epidemiol Date: 2009-01-19 Impact factor: 4.897
Authors: Aaron J Specht; Aisha S Dickerson; Kale Z Kponee-Shovein; Kpobari W Nkpaa; Marc G Weisskopf Journal: Bull Environ Contam Toxicol Date: 2019-11-14 Impact factor: 2.151
Authors: Jinming Zhang; Jennifer M Cavallari; Shona C Fang; Marc G Weisskopf; Xihong Lin; Murray A Mittleman; David C Christiani Journal: Occup Environ Med Date: 2017-06-29 Impact factor: 4.402
Authors: Catherine M Bulka; Martha L Daviglus; Victoria W Persky; Ramon A Durazo-Arvizu; James P Lash; Tali Elfassy; David J Lee; Alberto R Ramos; Wassim Tarraf; Maria Argos Journal: Heart Date: 2018-12-11 Impact factor: 7.365
Authors: Antonio J Signes-Pastor; Enrique Gutiérrez-González; Miguel García-Villarino; Francisco D Rodríguez-Cabrera; Jorge J López-Moreno; Elena Varea-Jiménez; Roberto Pastor-Barriuso; Marina Pollán; Ana Navas-Acien; Beatriz Pérez-Gómez; Margaret R Karagas Journal: Environ Res Date: 2020-10-16 Impact factor: 6.498