Literature DB >> 25738599

[4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes with simple olefins: facile approaches to tetrahydropyridazines.

Xingren Zhong1,2, Jian Lv1,2, Sanzhong Luo1,2.   

Abstract

A catalyst-free [4 + 2] annulation process between in situ generated 1,2-diaza-1,3-butadienes and simple olefins has been developed. Under mild conditions, the reactions afforded 1,4,5,6-tetrahydropyridazines, which feature a wide range of bioactive compounds, with high yields (up to 99% yield).

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Year:  2015        PMID： 25738599     DOI： 10.1021/acs.orglett.5b00445

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Hetero-Diels-Alder Reactions of In Situ-Generated Azoalkenes with Thioketones; Experimental and Theoretical Studies.

Authors:  Grzegorz Mlostoń; Katarzyna Urbaniak; Malwina Sobiecka; Heinz Heimgartner; Ernst-Ulrich Würthwein; Reinhold Zimmer; Dieter Lentz; Hans-Ulrich Reissig
Journal:  Molecules       Date:  2021-04-27       Impact factor: 4.411

2.  Synthesis of 1,4,5,6-tetrahydropyridazines and pyridazines via transition-metal-free (4 + 2) cycloaddition of alkoxyallenes with 1,2-diaza-1,3-dienes.

Authors:  Qi Wu; Pan-Lin Shao; Yun He
Journal:  RSC Adv       Date:  2019-07-10       Impact factor: 4.036
  2 in total

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