Literature DB >> 25738453

A mitochondrially encoded hormone ameliorates obesity and insulin resistance.

Kim Zarse1, Michael Ristow2.   

Abstract

MOTS-c, a mitochondrially encoded open reading frame-derived peptide recently discovered by Lee et al. 2015 (this issue of Cell Metabolism) promotes biosynthesis of an endogenous AMP analog, AICAR. As AICAR activates AMPK, the discovery of MOTS-c offers an unexpected therapeutic option to be exploited toward the prevention of type 2 diabetes and delaying of the aging processes.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25738453     DOI： 10.1016/j.cmet.2015.02.013

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  17 in total

Review 1.  Mitochondrial remodeling: Rearranging, recycling, and reprogramming.

Authors:  Roberta A Gottlieb; Daniel Bernstein
Journal:  Cell Calcium       Date:  2016-04-20       Impact factor: 6.817

2.  Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.

Authors:  Daniel L Morris; David W Kastner; Sabrina Johnson; Marie-Paule Strub; Yi He; Christopher K E Bleck; Duck-Yeon Lee; Nico Tjandra
Journal:  J Biol Chem       Date:  2019-11-05       Impact factor: 5.157

3.  Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.

Authors:  Adela Ramirez-Torres; Allison L Reagan; Lauren E Howard; Emily Wiggins; Adriana C Vidal; Junxiang Wan; Brendan Miller; Stephen J Freedland; Pinchas Cohen
Journal:  Prostate       Date:  2022-07-05       Impact factor: 4.012

Review 4.  MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Authors:  Bérénice A Benayoun; Changhan Lee
Journal:  Bioessays       Date:  2019-08-05       Impact factor: 4.345

Review 5.  MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.

Authors:  Changhan Lee; Kyung Hwa Kim; Pinchas Cohen
Journal:  Free Radic Biol Med       Date:  2016-05-20       Impact factor: 7.376

6.  Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism.

Authors:  Gil Myoung Kang; Se Hee Min; Chan Hee Lee; Ji Ye Kim; Hyo Sun Lim; Min Jeong Choi; Saet-Byel Jung; Jae Woo Park; Seongjun Kim; Chae Beom Park; Hong Dugu; Jong Han Choi; Won Hee Jang; Se Eun Park; Young Min Cho; Jae Geun Kim; Kyung-Gon Kim; Cheol Soo Choi; Young-Bum Kim; Changhan Lee; Minho Shong; Min-Seon Kim
Journal:  Cell Metab       Date:  2021-02-02       Impact factor: 27.287

Review 7.  Systemic Regulators of Skeletal Muscle Regeneration in Obesity.

Authors:  Indranil Sinha; Dharaniya Sakthivel; David E Varon
Journal:  Front Endocrinol (Lausanne)       Date:  2017-02-16       Impact factor: 5.555

Review 8.  Exercise mimetics: harnessing the therapeutic effects of physical activity.

Authors:  Carolina Gubert; Anthony J Hannan
Journal:  Nat Rev Drug Discov       Date:  2021-06-08       Impact factor: 84.694

9.  The impact of probiotics' administration on glycemic control, body composition, gut microbiome, mitochondria, and other hormonal signals in adolescents with prediabetes - A randomized, controlled trial study protocol.

Authors:  Charikleia Stefanaki; Flora Bacopoulou; Athanasios Michos
Journal:  Contemp Clin Trials Commun       Date:  2018-06-02

10.  A Mitochondrial Encoded Messenger at the Nucleus.

Authors:  Cheryl Qian Ying Yong; Bor Luen Tang
Journal:  Cells       Date:  2018-08-13       Impact factor: 6.600
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