| Literature DB >> 25738409 |
Yuan Ma1, Bo Qu, Xun Xia, Libin Yang, Yongqin Kuang, Tao Yang, Jingmin Cheng, Haodong Sun, Kexia Fan, Jianwen Gu.
Abstract
Thrombospondin-1 (TSP1) plays a role in the immune tolerance, and is involved in the pathogenesis of glioma. This study aims to investigate the role of the glioma-derived TSP1 in the induction of the tumor immune tolerance. The results showed that the primary human glioma cells expressed high levels of TSP1. Glioma cells enhanced the expression of transforming growth factor (TGF)-β in CD4⁺ CD16⁻ naïve monocytes (Mos). The TGF-β⁺ Mos showed inhibitory effect on CD8⁺ T cell proliferation. We conclude that glioma cell-derived TSP1 facilitates the induction of TGF-β in Mos. The TSP1 may be a potential therapeutic target of glioma.Entities:
Keywords: Glioma; Immune tolerance; Monocytes; Thrombospondin-1; Transforming growth factor-β
Mesh：
Substances：
Year: 2015 PMID： 25738409 DOI： 10.3109/07357907.2015.1010089
Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176