| Literature DB >> 25738382 |
Nadia J Kershaw1, Jeffrey J Babon2.
Abstract
Hypoxia inducible factor (HIF)-mediated response to hypoxic conditions is turned off by VHL-mediated ubiquitination of HIFα. To achieve this, VHL binds HIFα and recruits it to a specific E3 ubiquitin ligase complex, a Cullin-RING-ligase. In this issue of Structure, Nguyen et al. provide a structural view of how VHL engages the ligase in order to inhibit the hypoxic response.Entities:
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Year: 2015 PMID： 25738382 DOI： 10.1016/j.str.2015.02.003
Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006