Seema Nayak1, Saumya Chandra1, Divya Mehrotra2, Sumit Kumar3, S P Agrawal4, Sandeep Kumar5, Madhu Mati Goel6. 1. PhD Scholar, Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India. 2. Professor, Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow 226003, Uttar Pradesh, India. 3. PhD Scholar, Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow 226003, Uttar Pradesh, India. 4. Professor and Head, Department of Otolaryngology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India. 5. Director, All India Institute of Medical Sciences, Bhopal 462026, Madhya Pradesh, India. 6. Professor, Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India.
Abstract
OBJECTIVES: To assess the effect of risk factors tobacco, alcohol, and smoking habits in oral precancer patients with epithelial dysplasia status. MATERIAL AND METHODS: The study sample included biopsy proven cases of 29 oral submucous fibrosis (OSMF) and 43 cases of clinical leukoplakia. Histopathological diagnosis was made from formalin fixed paraffin embedded tissues as per WHO criteria. The relevant clinical and demographic details were recorded after interviewing the patients. Risk for tobacco, alcohol and smoking was determined by logistic regression analysis by SPSS software. RESULTS: Presence of epithelial dysplasia was significantly associated with tobacco in OSMF & both tobacco and smoking habits in leukoplakia. In OSMF tobacco was associated with 14.16-fold (95% CI, 1.36-147.07; p < 0.026) and in leukoplakia tobacco was associated with 4.66-fold (95% CI, 1.00-21.63; p < 0.047) and smoking was associated with 9.20-fold (95% CI, 1.65-51.28; p < 0.011) increased risk of epithelial dysplasia. CONCLUSION: Tobacco consumption was independent risk factor for epithelial dysplasia in OSMF and both tobacco and cigarette smoking were independent factors for epithelial dysplasia in leukoplakia.
OBJECTIVES: To assess the effect of risk factors tobacco, alcohol, and smoking habits in oral precancer patients with epithelial dysplasia status. MATERIAL AND METHODS: The study sample included biopsy proven cases of 29 oral submucous fibrosis (OSMF) and 43 cases of clinical leukoplakia. Histopathological diagnosis was made from formalin fixed paraffin embedded tissues as per WHO criteria. The relevant clinical and demographic details were recorded after interviewing the patients. Risk for tobacco, alcohol and smoking was determined by logistic regression analysis by SPSS software. RESULTS: Presence of epithelial dysplasia was significantly associated with tobacco in OSMF & both tobacco and smoking habits in leukoplakia. In OSMF tobacco was associated with 14.16-fold (95% CI, 1.36-147.07; p < 0.026) and in leukoplakiatobacco was associated with 4.66-fold (95% CI, 1.00-21.63; p < 0.047) and smoking was associated with 9.20-fold (95% CI, 1.65-51.28; p < 0.011) increased risk of epithelial dysplasia. CONCLUSION:Tobacco consumption was independent risk factor for epithelial dysplasia in OSMF and both tobacco and cigarette smoking were independent factors for epithelial dysplasia in leukoplakia.
Authors: M Hashibe; R Sankaranarayanan; G Thomas; B Kuruvilla; B Mathew; T Somanathan; D M Parkin; Z F Zhang Journal: Int J Cancer Date: 2000-10-01 Impact factor: 7.396
Authors: J A Brennan; J O Boyle; W M Koch; S N Goodman; R H Hruban; Y J Eby; M J Couch; A A Forastiere; D Sidransky Journal: N Engl J Med Date: 1995-03-16 Impact factor: 91.245