| Literature DB >> 25736995 |
Wei Su1, Jianping Zhao2, Min Yang3, Hui-Wen Yan4, Tao Pang5, Sheng-Huang Chen1, Hui-Yong Huang1, Shui-Han Zhang1, Xiao-Chi Ma6, De-An Guo3, Ikhlas A Khan2, Wei Wang7.
Abstract
Coumarinlignan (1), possessing a unique coumarin-containing lignan skeleton, was isolated from the stems of Kadsura heteroclita. Its structure and absolute configuration were determined by spectroscopic techniques, especially 2D NMR and X-ray crystallographic data analyses. The proposed biosynthetic pathway is discussed. This new compound showed good anti-HBV activity against HBeAg and HBsAg, and moderate anti-fibrotic and neuroprotective activities.Entities:
Keywords: Anti-HBV activity; Coumarin lignoid; Coumarinlignan; Kadsura heteroclita
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Year: 2015 PMID： 25736995 DOI： 10.1016/j.bmcl.2015.02.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823