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Literature DB >> 25736377

Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity.

Abstract

Obesity is a global concern, which has been linked to increased risk for cardiovascular disease, type 2 diabetes, atherosclerosis,non-alcoholic fatty liver, and cancer. In this issue of The EMBO Journal,Fujita et al (2015) describe the role of an endoplasmic reticulum (ER)-resident E3ubiquitin ligase, synoviolin, and its ability to control body weight and energy expenditure by targeting PGC-1b, a transcriptional modulator of mitochondrial oxidative metabolism.

Entities: Disease Gene

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Year: 2015 PMID： 25736377 PMCID： PMC4406646 DOI： 10.15252/embj.201591240

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

Keyword Cloud
References

11 in total

1. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects.

Authors: Neeraj K Sharma; Swapan K Das; Ashis K Mondal; Oksana G Hackney; Winston S Chu; Philip A Kern; Neda Rasouli; Horace J Spencer; Aiwei Yao-Borengasser; Steven C Elbein
Journal: J Clin Endocrinol Metab Date: 2008-08-26 Impact factor: 5.958

Review 2. Signal integration in the endoplasmic reticulum unfolded protein response.

Authors: David Ron; Peter Walter
Journal: Nat Rev Mol Cell Biol Date: 2007-07 Impact factor: 94.444

3. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

Authors: N W Bays; R G Gardner; L P Seelig; C A Joazeiro; R Y Hampton
Journal: Nat Cell Biol Date: 2001-01 Impact factor: 28.824

4. The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.

Authors: Hidetoshi Fujita; Naoko Yagishita; Satoko Aratani; Tomoko Saito-Fujita; Saori Morota; Yoshihisa Yamano; Magnus J Hansson; Masato Inazu; Hiroko Kokuba; Katsuko Sudo; Eiichi Sato; Ko-Ichi Kawahara; Fukami Nakajima; Daisuke Hasegawa; Itsuro Higuchi; Tomoo Sato; Natsumi Araya; Chie Usui; Kenya Nishioka; Yu Nakatani; Ikuro Maruyama; Masahiko Usui; Naomi Hara; Hiroyuki Uchino; Eskil Elmer; Kusuki Nishioka; Toshihiro Nakajima
Journal: EMBO J Date: 2015-02-19 Impact factor: 11.598

Review 5. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.

Authors: Pere Puigserver; Bruce M Spiegelman
Journal: Endocr Rev Date: 2003-02 Impact factor: 19.871

Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity.

1. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects.

Review 2. Signal integration in the endoplasmic reticulum unfolded protein response.

3. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

4. The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.

Review 5. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.

6. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.

Review 7. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.

Review 8. Cellular bioenergetics as a target for obesity therapy.

Review 9. Synoviolin, protein folding and the maintenance of joint homeostasis.

10. RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis.