Tengfei Wang1. 1. Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address: twang18@uthsc.edu.
Abstract
BACKGROUND AND AIMS: Tumor necrosis factor (TNF)-alpha G308A polymorphism has been reported in the association with susceptibility to Alzheimer's disease (AD); however, results have been contradictory. We conducted an updated meta-analysis to evaluate the role of TNF-alpha G308A in the occurrence of AD. METHODS: Relevant articles were retrieved from online databases. The combined odds ratio, odds ratio in different genetic models, and the related 95% confidence intervals were calculated. Publication bias and homogeneity among individual studies were estimated. Subgroup analyses and sensitivity analyses were also performed. RESULTS: In overall analyses, no risk of AD was associated with TNF-alpha G308A under different genetic models. However, in the subgroup analyses, a significant association between TNF-alpha G308A and AD risk was observed in Chinese. In addition, a significant protective effect of TNF-alpha -308A was found in the occurrence of AD among North European populations under a dominant model. CONCLUSIONS: The result of this meta-analysis suggests that TNF-alpha G308A polymorphism may be associated with the increased risk of AD in Chinese and decreased risk of AD in northern European populations.
BACKGROUND AND AIMS: Tumor necrosis factor (TNF)-alphaG308A polymorphism has been reported in the association with susceptibility to Alzheimer's disease (AD); however, results have been contradictory. We conducted an updated meta-analysis to evaluate the role of TNF-alphaG308A in the occurrence of AD. METHODS: Relevant articles were retrieved from online databases. The combined odds ratio, odds ratio in different genetic models, and the related 95% confidence intervals were calculated. Publication bias and homogeneity among individual studies were estimated. Subgroup analyses and sensitivity analyses were also performed. RESULTS: In overall analyses, no risk of AD was associated with TNF-alphaG308A under different genetic models. However, in the subgroup analyses, a significant association between TNF-alphaG308A and AD risk was observed in Chinese. In addition, a significant protective effect of TNF-alpha -308A was found in the occurrence of AD among North European populations under a dominant model. CONCLUSIONS: The result of this meta-analysis suggests that TNF-alphaG308A polymorphism may be associated with the increased risk of AD in Chinese and decreased risk of AD in northern European populations.
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