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Literature DB >> 25735612

Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy.

Nilay Thakkar¹, A Craig Lockhart, Wooin Lee.

Abstract

The superfamily of organic anion-transporting polypeptides (OATPs, gene symbol SLCO) includes important transporters handling a variety of endogenous and xenobiotic substrates. Currently, 11 human OATPs are known and their substrates include endogenous hormones and their conjugates, anticancer drugs, and imaging agents. The contribution of OATPs to the in vivo disposition of these substrates has been extensively investigated. An accumulating body of evidence also indicates that the expression of some OATPs may be up- or downregulated in several types of cancers, suggesting potential pathogenic roles during the development and progression of cancer. Given that the role of OATPs in handling cancer therapeutics has been already covered by several excellent reviews, this review will focus on the recent progresses on the topic, in particular the role of OATPs in the disposition of anticancer drugs, the impact of OATP genetic variations on the function of OATPs, and the OATPs differentially expressed in cancer and their potential roles in cancer development, progression, and treatment.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 25735612 PMCID： PMC4406968 DOI： 10.1208/s12248-015-9740-x

Source DB: PubMed Journal: AAPS J ISSN： 1550-7416 Impact factor: 4.009

103 in total

1. Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).

Authors: Katrin Letschert; Dietrich Keppler; Jörg König
Journal: Pharmacogenetics Date: 2004-07

2. Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers.

Authors: S Oswald; A Nassif; C Modess; M Keiser; U Hanke; A Engel; D Lütjohann; W Weitschies; W Siegmund
Journal: Clin Pharmacol Ther Date: 2010-03-10 Impact factor: 6.875

3. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

Authors: T Abe; M Unno; T Onogawa; T Tokui; T N Kondo; R Nakagomi; H Adachi; K Fujiwara; M Okabe; T Suzuki; K Nunoki; E Sato; M Kakyo; T Nishio; J Sugita; N Asano; M Tanemoto; M Seki; F Date; K Ono; Y Kondo; K Shiiba; M Suzuki; H Ohtani; T Shimosegawa; K Iinuma; H Nagura; S Ito; S Matsuno
Journal: Gastroenterology Date: 2001-06 Impact factor: 22.682

4. Genome-wide study of methotrexate clearance replicates SLCO1B1.

Authors: Laura B Ramsey; John C Panetta; Colton Smith; Wenjian Yang; Yiping Fan; Naomi J Winick; Paul L Martin; Cheng Cheng; Meenakshi Devidas; Ching-Hon Pui; William E Evans; Stephen P Hunger; Mignon Loh; Mary V Relling
Journal: Blood Date: 2012-12-11 Impact factor: 22.113

5. Pharmacogenetics of SLCO1B1 gene and the impact of 1b and 15 haplotypes on irinotecan disposition in Asian cancer patients.

Authors: Xiaoqiang Xiang; Srinivasa Rao Jada; Hui Hua Li; Lu Fan; Lai San Tham; Chiung Ing Wong; Soo Chin Lee; Robert Lim; Qing Yu Zhou; Boon Cher Goh; Eng Huat Tan; Balram Chowbay
Journal: Pharmacogenet Genomics Date: 2006-09 Impact factor: 2.089

6. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.

Authors: Ilaria Badagnani; Richard A Castro; Travis R Taylor; Claire M Brett; Conrad C Huang; Douglas Stryke; Michiko Kawamoto; Susan J Johns; Thomas E Ferrin; Elaine J Carlson; Esteban G Burchard; Kathleen M Giacomini
Journal: J Pharmacol Exp Ther Date: 2006-05-15 Impact factor: 4.030

7. Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells.

Authors: Miki Nagai; Tomomi Furihata; Sayaka Matsumoto; Seiya Ishii; Shinichiro Motohashi; Ichiro Yoshino; Miyuki Ugajin; Atsushi Miyajima; Shogo Matsumoto; Kan Chiba
Journal: Biochem Biophys Res Commun Date: 2012-01-30 Impact factor: 3.575

8. The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.

Authors: Stephan R Vavricka; Diana Jung; Michael Fried; Uwe Grützner; Peter J Meier; Gerd A Kullak-Ublick
Journal: J Hepatol Date: 2004-02 Impact factor: 25.083

9. Molecular characterization of human and rat organic anion transporter OATP-D.

Authors: Hisanobu Adachi; Takehiro Suzuki; Michiaki Abe; Naoki Asano; Hiroya Mizutamari; Masayuki Tanemoto; Toshiyuki Nishio; Tohru Onogawa; Takafumi Toyohara; Satoshi Kasai; Fumitoshi Satoh; Masanori Suzuki; Taro Tokui; Michiaki Unno; Tooru Shimosegawa; Seiki Matsuno; Sadayoshi Ito; Takaaki Abe
Journal: Am J Physiol Renal Physiol Date: 2003-12

10. Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer.

Authors: Sang-Yull Lee; Barbara Williamson; Otavia L Caballero; Yao-Tseng Chen; Matthew J Scanlan; Gerd Ritter; C Victor Jongeneel; Andrew J G Simpson; Lloyd J Old
Journal: Cancer Immun Date: 2004-11-17

31 in total

1. A Near-IR Fluorescent Dasatinib Derivative That Localizes in Cancer Cells.

Authors: Syed Muhammad Usama; Bosheng Zhao; Kevin Burgess
Journal: Bioconjug Chem Date: 2019-04-01 Impact factor: 4.774

Review 2. Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion-transporting polypeptides.

Authors: Wooin Lee; Jeong-Min Ha; Yuichi Sugiyama
Journal: J Biol Chem Date: 2020-10-13 Impact factor: 5.157

Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy.

1. Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).

2. Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers.

3. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

4. Genome-wide study of methotrexate clearance replicates SLCO1B1.

5. Pharmacogenetics of SLCO1B1 gene and the impact of 1b and 15 haplotypes on irinotecan disposition in Asian cancer patients.

6. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.

7. Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells.

8. The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.

9. Molecular characterization of human and rat organic anion transporter OATP-D.

10. Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer.

1. A Near-IR Fluorescent Dasatinib Derivative That Localizes in Cancer Cells.

Review 2. Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion-transporting polypeptides.

Review 3. Alternative Splicing: Expanding Diversity in Major ABC and SLC Drug Transporters.

4. Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.

Review 5. Effect of Liver Disease on Hepatic Transporter Expression and Function.

Review 6. Organic Anion Transporting Polypeptides: Emerging Roles in Cancer Pharmacology.

Review 7. A guide to plasma membrane solute carrier proteins.

Review 8. Drug and Solute Transporters in Mediating Resistance to Novel Therapeutics in Multiple Myeloma.

Review 9. Interactions between cardiology and oncology drugs in precision cardio-oncology.

10. Role of Albumin in Accumulation and Persistence of Tumor-Seeking Cyanine Dyes.