E M Schumacher1, T A Stiris2, P G Larsson3. 1. University of Oslo, Faculty of Medicine, Department of Paediatrics, Oslo University Hospital Ullevaal, PB 4956, 0424 Oslo, Norway. 2. University of Oslo, Faculty of Medicine, Department of Neonatology, Oslo University Hospital Ullevaal, PB 4956, 0424 Oslo, Norway. 3. Clinical Neurophysiological Section, Department of Neurosurgery, Oslo University Hospital, PB 4950, 0424 Oslo, Norway. Electronic address: pall@ous-hf.no.
Abstract
OBJECTIVE: Electroencephalogram (EEG) is commonly used to monitor brain activity in preterm neonates. Long-term EEG is used to predict outcomes by total band power. This study reports effective connectivity analyses in the fronto-parietal network in preterm infants. METHOD: Directed transfer functions (DTFs) were used in fully automated calculations of effective connectivity. Continuous eight-channel EEG recordings were performed for three full days starting at a median of 5.3h (2.5-11.2h) after birth. Analyses were performed using the channels Fp1, Fp2, P3 and P4. DTF were calculated every second in every connection and channel for all frequencies from 1 Hz to 30 Hz. The median connectivity was used in the connectivity assessment. RESULTS: Parieto-frontal connectivity was significantly higher (0.22) than fronto-parietal connectivity (0.05). There was a significant decrease in parieto-frontal connectivity between day one (0.18) and three. Conversely, there was a significant increase in fronto-parietal connectivity from day one to day three (0.07). CONCLUSION: Significant changes are seen in connectivity from day one to three, but there were no certain connectivity differences between gestational ages. SIGNIFICANCE: A rapid change in fronto-parietal connectivity was seen from day one to three which may indicate fast postpartum maturation.
OBJECTIVE: Electroencephalogram (EEG) is commonly used to monitor brain activity in preterm neonates. Long-term EEG is used to predict outcomes by total band power. This study reports effective connectivity analyses in the fronto-parietal network in preterm infants. METHOD: Directed transfer functions (DTFs) were used in fully automated calculations of effective connectivity. Continuous eight-channel EEG recordings were performed for three full days starting at a median of 5.3h (2.5-11.2h) after birth. Analyses were performed using the channels Fp1, Fp2, P3 and P4. DTF were calculated every second in every connection and channel for all frequencies from 1 Hz to 30 Hz. The median connectivity was used in the connectivity assessment. RESULTS: Parieto-frontal connectivity was significantly higher (0.22) than fronto-parietal connectivity (0.05). There was a significant decrease in parieto-frontal connectivity between day one (0.18) and three. Conversely, there was a significant increase in fronto-parietal connectivity from day one to day three (0.07). CONCLUSION: Significant changes are seen in connectivity from day one to three, but there were no certain connectivity differences between gestational ages. SIGNIFICANCE: A rapid change in fronto-parietal connectivity was seen from day one to three which may indicate fast postpartum maturation.
Authors: Brigitta Tóth; Gábor Urbán; Gábor P Háden; Molnár Márk; Miklós Török; Cornelis Jan Stam; István Winkler Journal: Hum Brain Mapp Date: 2017-05-10 Impact factor: 5.038
Authors: N J Stevenson; L Oberdorfer; N Koolen; J M O'Toole; T Werther; K Klebermass-Schrehof; S Vanhatalo Journal: Sci Rep Date: 2017-10-11 Impact factor: 4.379