Literature DB >> 2573535

Novel alpha 2-adrenoceptor antagonists show selectivity for alpha 2A- and alpha 2B-adrenoceptor subtypes.

P Young1, J Berge, H Chapman, M A Cawthorne.   

Abstract

Pharmacological characterization of mammalian alpha 2-adrenoceptors in various tissues and species has provided evidence for the existence of two alpha 2-adrenoceptor subtypes. These subtypes can be defined in rat and human tissues by prazosin which is alpha 2B selective and oxymetazoline which is alpha 2A selective. In addition to these agents, two types of alpha 2-adrenoceptor antagonists are described which show high affinity and selectivity for the alpha 2A-adrenoceptor and the alpha 2B-adrenoceptor respectively.

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Year:  1989        PMID： 2573535     DOI： 10.1016/0014-2999(89)90801-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  20 in total

1.  Investigations of the subtype of alpha 2-adrenoceptor mediating contractions of the human saphenous vein.

Authors:  K Smith; S Connaughton; J R Docherty
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

2.  Alpha 2-autoreceptors and alpha 2-heteroreceptors modulating tyrosine and tryptophan hydroxylase activity in the rat brain in vivo: an investigation into the alpha 2-adrenoceptor subtypes.

Authors:  S Esteban; J Lladó; J A García-Sevilla
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-03       Impact factor: 3.000

3.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

4.  Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins.

Authors:  T Görnemann; H von Wenckstern; B Kleuser; C M Villalón; D Centurión; S Jähnichen; H H Pertz
Journal:  Br J Pharmacol       Date:  2007-03-20       Impact factor: 8.739

5.  Structural determinants of the alpha2 adrenoceptor subtype selectivity.

Authors:  Liliana Ostopovici-Halip; Ramona Curpăn; Maria Mracec; Cristian G Bologa
Journal:  J Mol Graph Model       Date:  2011-05-06       Impact factor: 2.518

6.  [3H]-MK 912 binding delineates two alpha 2-adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d alpha 2-adrenoceptor.

Authors:  S Uhlén; Y Xia; V Chhajlani; C C Felder; J E Wikberg
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

7.  Pharmacological characterization of presynaptic alpha 2-autoreceptors in rat submaxillary gland and heart atrium.

Authors:  N Limberger; A U Trendelenburg; K Starke
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

8.  A comparative study of the reversal by different alpha 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine.

Authors:  C Vayssettes-Courchay; F Bouysset; A A Cordi; M Laubie; T J Verbeuren
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

9.  Presynaptic alpha 2-autoreceptors in brain cortex: alpha 2D in the rat and alpha 2A in the rabbit.

Authors:  A U Trendelenburg; N Limberger; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-07       Impact factor: 3.000

10.  Alpha 2-autoreceptor subclassification in rat isolated kidney by use of short trains of electrical stimulation.

Authors:  C Bohmann; P Schollmeyer; L C Rump
Journal:  Br J Pharmacol       Date:  1993-01       Impact factor: 8.739
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