Literature DB >> 25734489

Intraoperative radiotherapy in early stage breast cancer: potential indications and evidence to date.

G G Hanna1, A M Kirby.   

Abstract

Following early results of recent studies of intraoperative radiotherapy (IORT) in the adjuvant treatment of patients with early breast cancer, the clinical utility of IORT is a subject of much recent debate within the breast oncology community. This review describes the intraoperative techniques available, the potential indications and the evidence to date pertaining to local control and toxicity. We also discuss any implications for current practice and future research.

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Year:  2015        PMID: 25734489      PMCID: PMC4628474          DOI: 10.1259/bjr.20140686

Source DB:  PubMed          Journal:  Br J Radiol        ISSN: 0007-1285            Impact factor:   3.039


  63 in total

Review 1.  Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials.

Authors:  M Clarke; R Collins; S Darby; C Davies; P Elphinstone; V Evans; J Godwin; R Gray; C Hicks; S James; E MacKinnon; P McGale; T McHugh; R Peto; C Taylor; Y Wang
Journal:  Lancet       Date:  2005-12-17       Impact factor: 79.321

2.  Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.

Authors:  Ian H Kunkler; Linda J Williams; Wilma J L Jack; David A Cameron; J Michael Dixon
Journal:  Lancet Oncol       Date:  2015-01-28       Impact factor: 41.316

3.  Intraoperative electron-beam therapy for primary and recurrent retroperitoneal soft-tissue sarcoma.

Authors:  Robert Krempien; Falk Roeder; Susanne Oertel; Jürgen Weitz; Frank W Hensley; Carmen Timke; Angela Funk; Katja Lindel; Wolfgang Harms; Markus W Buchler; Jürgen Debus; Martina Treiber
Journal:  Int J Radiat Oncol Biol Phys       Date:  2006-05-06       Impact factor: 7.038

4.  Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer.

Authors:  Randall J Kimple; Nancy Klauber-DeMore; Cherie M Kuzmiak; Dag Pavic; Jun Lian; Chad A Livasy; WingKeung M Chiu; Dominic T Moore; Carolyn I Sartor; David W Ollila
Journal:  Ann Surg Oncol       Date:  2011-04       Impact factor: 5.344

5.  Intraoperative radiation therapy in early breast cancer using a linear accelerator outside of the operative suite: an "image-guided" approach.

Authors:  Samir Abdallah Hanna; Alfredo Carlos Simões Dornellas de Barros; Felipe Eduardo Martins de Andrade; Jose Luiz Barbosa Bevilacqua; José Roberto Morales Piato; Edilson Lopes Pelosi; Eduardo Martella; João Luis Fernandes da Silva; Heloisa de Andrade Carvalho
Journal:  Int J Radiat Oncol Biol Phys       Date:  2014-07-08       Impact factor: 7.038

6.  Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO).

Authors:  Benjamin D Smith; Douglas W Arthur; Thomas A Buchholz; Bruce G Haffty; Carol A Hahn; Patricia H Hardenbergh; Thomas B Julian; Lawrence B Marks; Dorin A Todor; Frank A Vicini; Timothy J Whelan; Julia White; Jennifer Y Wo; Jay R Harris
Journal:  Int J Radiat Oncol Biol Phys       Date:  2009-07-15       Impact factor: 7.038

7.  Six-year outcome of a prospective study evaluating tumor bed boost with intra-operative electron irradiation followed by whole-breast irradiation for early-stage breast cancer.

Authors:  William W Wong; Barbara A Pockaj; Sujay A Vora; Michele Y Halyard; Richard J Gray; Steven E Schild
Journal:  Breast J       Date:  2013-12-26       Impact factor: 2.431

8.  Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy.

Authors:  B Elsberger; A Romsauerova; S Vinnicombe; P Whelehan; D C Brown; J A Dewar; A M Thompson; A Evans
Journal:  Eur J Surg Oncol       Date:  2013-12-04       Impact factor: 4.424

9.  Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer.

Authors:  Jude M Mulligan; Laura A Hill; Steve Deharo; Gareth Irwin; David Boyle; Katherine E Keating; Olaide Y Raji; Fionnuala A McDyer; Eamonn O'Brien; Max Bylesjo; Jennifer E Quinn; Noralane M Lindor; Paul B Mullan; Colin R James; Steven M Walker; Peter Kerr; Jacqueline James; Timothy S Davison; Vitali Proutski; Manuel Salto-Tellez; Patrick G Johnston; Fergus J Couch; D Paul Harkin; Richard D Kennedy
Journal:  J Natl Cancer Inst       Date:  2014-01       Impact factor: 13.506

10.  Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial.

Authors:  Jayant S Vaidya; Frederik Wenz; Max Bulsara; Jeffrey S Tobias; David J Joseph; Mohammed Keshtgar; Henrik L Flyger; Samuele Massarut; Michael Alvarado; Christobel Saunders; Wolfgang Eiermann; Marinos Metaxas; Elena Sperk; Marc Sütterlin; Douglas Brown; Laura Esserman; Mario Roncadin; Alastair Thompson; John A Dewar; Helle M R Holtveg; Steffi Pigorsch; Mary Falzon; Eleanor Harris; April Matthews; Chris Brew-Graves; Ingrid Potyka; Tammy Corica; Norman R Williams; Michael Baum
Journal:  Lancet       Date:  2013-11-11       Impact factor: 79.321

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  6 in total

Review 1.  Electronic brachytherapy--current status and future directions.

Authors:  D J Eaton
Journal:  Br J Radiol       Date:  2015-03-06       Impact factor: 3.039

2.  Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database.

Authors:  Juan Lei; Yi Wang; Zhuofei Bi; Shengneng Xue; Bing Ou; Kan Liu
Journal:  Jpn J Radiol       Date:  2019-11-05       Impact factor: 2.374

3.  Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.

Authors:  Ying Xu; Dongming Wu; Yuanchun Fan; Peigeng Li; Hongfei Du; Jiao Shi; Dan Wang; Xiaoping Zhou
Journal:  Oncol Lett       Date:  2016-08-05       Impact factor: 2.967

4.  Efficacy analysis of intraoperative radiotherapy in patients with early-stage breast cancer.

Authors:  Lin Wang; Minmin Zhu; Yuelong Cui; Xudong Zhang; Guowen Li
Journal:  Cancer Cell Int       Date:  2020-09-11       Impact factor: 5.722

5.  Comparison of the Oncological Efficacy Between Intraoperative Radiotherapy With Whole-Breast Irradiation for Early Breast Cancer: A Meta-Analysis.

Authors:  Lin He; Jiejing Zhou; Yuhong Qi; Dongjie He; Canliang Yuan; Hao Chang; Qiming Wang; Gaiyan Li; Qiuju Shao
Journal:  Front Oncol       Date:  2021-12-17       Impact factor: 6.244

6.  Prognosis comparison between intraoperative radiotherapy and whole-breast external beam radiotherapy for T1-2 stage breast cancer without lymph node metastasis treated with breast-conserving surgery: A case-control study after propensity score matching.

Authors:  Qitong Chen; Limeng Qu; Yeqing He; Jiachi Xu; Yueqiong Deng; Qin Zhou; Wenjun Yi
Journal:  Front Med (Lausanne)       Date:  2022-08-03
  6 in total

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