Literature DB >> 25734006

Dual secured nano-melittin for the safe and effective eradication of cancer cells.

Cheng Bei1, Thapa Bindu1, K C Remant1, Xu Peisheng1.   

Abstract

The clinical application of natural and synthetic amphipathic peptides (e.g., melittin) for cancer therapy is hindered by their notorious side effect, lysing red blood cells. To safely deliver a therapeutic peptide to the tumor tissue and kill cancer cells, we developed an environment-sensitive peptide delivery system, dual secured nano-sting (DSNS), through the combination of a zwitterionic glycol chitosan and disulfide bonds. Melittin loaded DSNS could kill almost 100% of MCF-7, HCT-116, SKOV-3, and NCI/ADR-RES (multidrug resistant) cancer cells at the concentration of 5 μM, while not showing any hemolytic effect.

Entities:  

Year:  2014        PMID： 25734006      PMCID： PMC4342614          DOI： 10.1039/C4TB01401D

Source DB:  PubMed          Journal:  J Mater Chem B        ISSN： 2050-750X            Impact factor:   6.331


  32 in total

1.  Design of serum compatible tetrary complexes for gene delivery.

Authors:  Remant Bahadur K C; Bindu Thapa; Peisheng Xu
Journal:  Macromol Biosci       Date:  2012-04-17       Impact factor: 4.979

2.  Truncated peptides from melittin and its analog with high lytic activity at endosomal pH enhance branched polyethylenimine-mediated gene transfection.

Authors:  Ying-Xia Tan; Chong Chen; Ying-Li Wang; Song Lin; Yang Wang; Su-Bo Li; Xiao-Pan Jin; Hong-Wei Gao; Fu-Sheng Du; Feng Gong; Shou-Ping Ji
Journal:  J Gene Med       Date:  2012-04       Impact factor: 4.565

3.  Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET.

Authors:  Yi-Ping Ho; Hunter H Chen; Kam W Leong; Tza-Huei Wang
Journal:  J Control Release       Date:  2006-09-22       Impact factor: 9.776

4.  Targeted charge-reversal nanoparticles for nuclear drug delivery.

Authors:  Peisheng Xu; Edward A Van Kirk; Yihong Zhan; William J Murdoch; Maciej Radosz; Youqing Shen
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

5.  Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.

Authors:  Levi A Garraway; Hans R Widlund; Mark A Rubin; Gad Getz; Aaron J Berger; Sridhar Ramaswamy; Rameen Beroukhim; Danny A Milner; Scott R Granter; Jinyan Du; Charles Lee; Stephan N Wagner; Cheng Li; Todd R Golub; David L Rimm; Matthew L Meyerson; David E Fisher; William R Sellers
Journal:  Nature       Date:  2005-07-07       Impact factor: 49.962

6.  Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue.

Authors:  W F DeGrado; G F Musso; M Lieber; E T Kaiser; F J Kézdy
Journal:  Biophys J       Date:  1982-01       Impact factor: 4.033

7.  Hybrid melittin cytolytic Peptide-driven ultrasmall lipid nanoparticles block melanoma growth in vivo.

Authors:  Chuan Huang; Honglin Jin; Yuan Qian; Shuhong Qi; Haiming Luo; Qingming Luo; Zhihong Zhang
Journal:  ACS Nano       Date:  2013-06-26       Impact factor: 15.881

8.  Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-κB.

Authors:  Mi Hee Park; Myoung Suk Choi; Dong Hoon Kwak; Ki-Wan Oh; Do Young Yoon; Sang Bae Han; Ho Sueb Song; Min Jong Song; Jin Tae Hong
Journal:  Prostate       Date:  2010-11-17       Impact factor: 4.104

9.  FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes.

Authors:  Christopher A Alabi; Kevin T Love; Gaurav Sahay; Tina Stutzman; Whitney T Young; Robert Langer; Daniel G Anderson
Journal:  ACS Nano       Date:  2012-06-22       Impact factor: 15.881

10.  The carbamoylmannose moiety of bleomycin mediates selective tumor cell targeting.

Authors:  Chandrabali Bhattacharya; Zhiqiang Yu; Michael J Rishel; Sidney M Hecht
Journal:  Biochemistry       Date:  2014-05-13       Impact factor: 3.162
View more
  13 in total

Review 1.  Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy.

Authors:  Islam Rady; Imtiaz A Siddiqui; Mohamad Rady; Hasan Mukhtar
Journal:  Cancer Lett       Date:  2017-05-20       Impact factor: 8.679

2.  Cancer cell-selective killing polymer/copper combination.

Authors:  Huacheng He; Diego Altomare; Ufuk Ozer; Hanwen Xu; Kim Creek; Hexin Chen; Peisheng Xu
Journal:  Biomater Sci       Date:  2016-01       Impact factor: 6.843

3.  Quantitative Measurement of Melittin in Asian Honeybee Venom Using a New Method Including UPLC-QqTOF-MS.

Authors:  Sheng Huang; Jianhua Wang; Zeqin Guo; Yan Wang; Chundong Liu
Journal:  Toxins (Basel)       Date:  2020-07-04       Impact factor: 4.546

Review 4.  Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests.

Authors:  Rim Wehbe; Jacinthe Frangieh; Mohamad Rima; Dany El Obeid; Jean-Marc Sabatier; Ziad Fajloun
Journal:  Molecules       Date:  2019-08-19       Impact factor: 4.411

Review 5.  Subcellular Performance of Nanoparticles in Cancer Therapy.

Authors:  Chen-Guang Liu; Ya-Hui Han; Ranjith Kumar Kankala; Shi-Bin Wang; Ai-Zheng Chen
Journal:  Int J Nanomedicine       Date:  2020-02-05

Review 6.  Thiolated-Polymer-Based Nanoparticles as an Avant-Garde Approach for Anticancer Therapies-Reviewing Thiomers from Chitosan and Hyaluronic Acid.

Authors:  Roberto Grosso; M-Violante de-Paz
Journal:  Pharmaceutics       Date:  2021-06-08       Impact factor: 6.321

7.  The membrane effects of melittin on gastric and colorectal cancer.

Authors:  Caroline Soliman; Sarah Eastwood; Vi Khanh Truong; Paul A Ramsland; Aaron Elbourne
Journal:  PLoS One       Date:  2019-10-17       Impact factor: 3.240

Review 8.  Apitoxin and Its Components against Cancer, Neurodegeneration and Rheumatoid Arthritis: Limitations and Possibilities.

Authors:  Andreas Aufschnaiter; Verena Kohler; Shaden Khalifa; Aida Abd El-Wahed; Ming Du; Hesham El-Seedi; Sabrina Büttner
Journal:  Toxins (Basel)       Date:  2020-01-21       Impact factor: 4.546

9.  Redox-Sensitive Nanocomplex for Targeted Delivery of Melittin.

Authors:  Bei Cheng; Peisheng Xu
Journal:  Toxins (Basel)       Date:  2020-09-10       Impact factor: 4.546

10.  Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer.

Authors:  Ciara Duffy; Anabel Sorolla; Edina Wang; Emily Golden; Eleanor Woodward; Kathleen Davern; Diwei Ho; Elizabeth Johnstone; Kevin Pfleger; Andrew Redfern; K Swaminathan Iyer; Boris Baer; Pilar Blancafort
Journal:  NPJ Precis Oncol       Date:  2020-09-01
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.