OBJECTIVES: Adenosine to inosine RNA editing, serotonin 2C receptor (HTR2C), and stressful life events (SLEs) have all been implicated in suicidal behaviour. We examined the main and moderating effects of RNA editing (ADAR, ADARB1) and HTR2C genes, childhood trauma (CT), recent SLEs and psychiatric disorders as contributors to suicide attempt (SA) vulnerability. METHODS: Study included 165 suicide attempters and 188 suicide non-attempters, all diagnosed with one of major psychiatric disorders. CT and recent SLEs were assessed using Early Trauma Inventory-Self Report and List of Threatening Experiences Questionnaire, respectively. Selected ADAR and ADARB1 tag-variants, and HTR2C rs6318 were pre-screened for association with SA, while generalized linear models and backward selection were applied to identify individual and interacting SA risk factors. RESULTS: ADARB1 rs9983925 and rs4819035 and HTR2C rs6318 were associated with SA. The best minimal model found emotional abuse, recent SLEs, rs9983925 and rs6318 as independent SA risk factors, and general traumas as a factor moderating the effect of psychiatric disorders and emotional abuse. CONCLUSIONS: SA vulnerability in psychiatric patients is related to the joint effect of ADARB1 and HTR2C variants, the existing mood disorder and the cumulative exposures to a various childhood and recent stressful experiences.
OBJECTIVES:Adenosine to inosine RNA editing, serotonin 2C receptor (HTR2C), and stressful life events (SLEs) have all been implicated in suicidal behaviour. We examined the main and moderating effects of RNA editing (ADAR, ADARB1) and HTR2C genes, childhood trauma (CT), recent SLEs and psychiatric disorders as contributors to suicide attempt (SA) vulnerability. METHODS: Study included 165 suicide attempters and 188 suicide non-attempters, all diagnosed with one of major psychiatric disorders. CT and recent SLEs were assessed using Early Trauma Inventory-Self Report and List of Threatening Experiences Questionnaire, respectively. Selected ADAR and ADARB1 tag-variants, and HTR2Crs6318 were pre-screened for association with SA, while generalized linear models and backward selection were applied to identify individual and interacting SA risk factors. RESULTS:ADARB1rs9983925 and rs4819035 and HTR2Crs6318 were associated with SA. The best minimal model found emotional abuse, recent SLEs, rs9983925 and rs6318 as independent SA risk factors, and general traumas as a factor moderating the effect of psychiatric disorders and emotional abuse. CONCLUSIONS: SA vulnerability in psychiatricpatients is related to the joint effect of ADARB1 and HTR2C variants, the existing mood disorder and the cumulative exposures to a various childhood and recent stressful experiences.
Authors: Jelena Karanović; Maja Ivković; Vladimir M Jovanović; Saša Šviković; Maja Pantović-Stefanović; Miloš Brkušanin; Aleksandar Damjanović; Goran Brajušković; Dušanka Savić-Pavićević Journal: J Neural Transm (Vienna) Date: 2017-01-13 Impact factor: 3.575
Authors: Gabriel Molina-Guzman; Thelma Beatriz González-Castro; Yazmín Hernández Díaz; Carlos Alfonso Tovilla-Zárate; Isela E Juárez-Rojop; Crystell Guadalupe Guzmán-Priego; Alma Genis; Sherezada Pool García; María Lilia López-Narvaez; José Manuel Rodriguez-Perez Journal: Neuropsychiatr Dis Treat Date: 2017-02-22 Impact factor: 2.570
Authors: D Weissmann; S van der Laan; M D Underwood; N Salvetat; L Cavarec; L Vincent; F Molina; J J Mann; V Arango; J F Pujol Journal: Transl Psychiatry Date: 2016-08-30 Impact factor: 6.222
Authors: Anastasia Levchenko; Natalia M Vyalova; Timur Nurgaliev; Ivan V Pozhidaev; German G Simutkin; Nikolay A Bokhan; Svetlana A Ivanova Journal: Front Genet Date: 2020-08-25 Impact factor: 4.599