Darius Henatsch1, Frederik Wesseling, Jacob J Briedé, Robert J Stokroos. 1. *Department of Otorhinolaryngology-Head and Neck Surgery, Maastricht University Medical Center; and †Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands.
Abstract
OBJECTIVE: To investigate the efficacy of medical honey as topical treatment of chronically discharging open mastoid cavities in comparison with conventional eardrops. STUDY DESIGN: Single-center, prospective, randomized controlled, double-dose trial of 12 weeks. PATIENTS AND INTERVENTION: Twenty-eight patients diagnosed as having a chronically discharging open mastoid cavity underwentmedical honey gel (intervention) or conventional eardrops (control) treatment. Treatment interventions were repeated after 4 weeks. MAIN OUTCOME MEASURES: Visual analogue scale of ear complaints, cavity inflammation, and bacterial infection. RESULTS:Most patients had a cavity with localized granulation. After treatment, inflammation score decreased in both groups (p < 0.05), with more pronounced inflammation-free cavities in the honey group. Honey treatment resulted in less discomfort (p < 0.001) and otorrhea (p < 0.001), even after correction for additional medication use (p < 0.05, p < 0.01). This decrease was not seen in the control group. Pain and itching did not change on treatment. Most cavities were infected with Pseudomonas species and Staphylococcus aureus. After treatment, a 23% increase of negative culture was seen with honey compared with 30% in the control group (nonsignificant). No serious adverse reactions were found. CONCLUSION: Medical honey gel is a safe alternative treatment option for patients with a chronically discharging open mastoid cavity and beneficial in reducing discomfort, otorrhea, and inflammation with a bactericidal effect.
RCT Entities:
OBJECTIVE: To investigate the efficacy of medical honey as topical treatment of chronically discharging open mastoid cavities in comparison with conventional eardrops. STUDY DESIGN: Single-center, prospective, randomized controlled, double-dose trial of 12 weeks. PATIENTS AND INTERVENTION: Twenty-eight patients diagnosed as having a chronically discharging open mastoid cavity underwent medical honey gel (intervention) or conventional eardrops (control) treatment. Treatment interventions were repeated after 4 weeks. MAIN OUTCOME MEASURES: Visual analogue scale of ear complaints, cavity inflammation, and bacterial infection. RESULTS: Most patients had a cavity with localized granulation. After treatment, inflammation score decreased in both groups (p < 0.05), with more pronounced inflammation-free cavities in the honey group. Honey treatment resulted in less discomfort (p < 0.001) and otorrhea (p < 0.001), even after correction for additional medication use (p < 0.05, p < 0.01). This decrease was not seen in the control group. Pain and itching did not change on treatment. Most cavities were infected with Pseudomonas species and Staphylococcus aureus. After treatment, a 23% increase of negative culture was seen with honey compared with 30% in the control group (nonsignificant). No serious adverse reactions were found. CONCLUSION: Medical honey gel is a safe alternative treatment option for patients with a chronically discharging open mastoid cavity and beneficial in reducing discomfort, otorrhea, and inflammation with a bactericidal effect.
Authors: Darius Henatsch; Sultan Alsulami; Adriaan M Duijvestijn; Jack P Cleutjens; Carine J Peutz-Kootstra; Robert J Stokroos Journal: JAMA Otolaryngol Head Neck Surg Date: 2018-03-01 Impact factor: 6.223
Authors: Domen Vozel; Darja Božič; Marko Jeran; Zala Jan; Manca Pajnič; Ljubiša Pađen; Nejc Steiner; Veronika Kralj-Iglič; Saba Battelino Journal: Front Bioeng Biotechnol Date: 2021-07-07