Ann J Hessell1, Nancy L Haigwood. 1. Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Abstract
PURPOSE OF REVIEW: The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. RECENT FINDINGS: Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. SUMMARY: Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies.
PURPOSE OF REVIEW: The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. RECENT FINDINGS: Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. SUMMARY: Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies.
Authors: T W Baba; V Liska; R Hofmann-Lehmann; J Vlasak; W Xu; S Ayehunie; L A Cavacini; M R Posner; H Katinger; G Stiegler; B J Bernacky; T A Rizvi; R Schmidt; L R Hill; M E Keeling; Y Lu; J E Wright; T C Chou; R M Ruprecht Journal: Nat Med Date: 2000-02 Impact factor: 53.440
Authors: Maria Salgado; Michael D Swanson; Christopher W Pohlmeyer; Robert W Buckheit; Jin Wu; Nancie M Archin; Thomas M Williams; David M Margolis; Robert F Siliciano; J Victor Garcia; Joel N Blankson Journal: J Virol Date: 2014-01-03 Impact factor: 5.103
Authors: John Pietzsch; Henning Gruell; Stylianos Bournazos; Bridget M Donovan; Florian Klein; Ron Diskin; Michael S Seaman; Pamela J Bjorkman; Jeffrey V Ravetch; Alexander Ploss; Michel C Nussenzweig Journal: Proc Natl Acad Sci U S A Date: 2012-09-10 Impact factor: 11.205
Authors: Patrick Smith; David J DiLillo; Stylianos Bournazos; Fubin Li; Jeffrey V Ravetch Journal: Proc Natl Acad Sci U S A Date: 2012-04-02 Impact factor: 11.205
Authors: Michael A Thomas; Thorsten Demberg; Diego A Vargas-Inchaustegui; Peng Xiao; Iskra Tuero; David Venzon; Deborah Weiss; James Treece; Marjorie Robert-Guroff Journal: Vaccine Date: 2013-12-25 Impact factor: 3.641
Authors: Mario Roederer; Brandon F Keele; Stephen D Schmidt; Rosemarie D Mason; Hugh C Welles; Will Fischer; Celia Labranche; Kathryn E Foulds; Mark K Louder; Zhi-Yong Yang; John-Paul M Todd; Adam P Buzby; Linh V Mach; Ling Shen; Kelly E Seaton; Brandy M Ward; Robert T Bailer; Raphael Gottardo; Wenjuan Gu; Guido Ferrari; S Munir Alam; Thomas N Denny; David C Montefiori; Georgia D Tomaras; Bette T Korber; Martha C Nason; Robert A Seder; Richard A Koup; Norman L Letvin; Srinivas S Rao; Gary J Nabel; John R Mascola Journal: Nature Date: 2013-12-18 Impact factor: 49.962
Authors: Ann J Hessell; Eva G Rakasz; Pascal Poignard; Lars Hangartner; Gary Landucci; Donald N Forthal; Wayne C Koff; David I Watkins; Dennis R Burton Journal: PLoS Pathog Date: 2009-05-15 Impact factor: 6.823
Authors: Sallie Permar; Ofer Levy; Tobias R Kollman; Anjali Singh; Kristina De Paris Journal: AIDS Res Hum Retroviruses Date: 2018-07-03 Impact factor: 2.205
Authors: Colin Havenar-Daughton; Samantha M Reiss; Diane G Carnathan; Jennifer E Wu; Kayla Kendric; Alba Torrents de la Peña; Sudhir Pai Kasturi; Jennifer M Dan; Marcella Bothwell; Rogier W Sanders; Bali Pulendran; Guido Silvestri; Shane Crotty Journal: J Immunol Date: 2016-06-22 Impact factor: 5.422
Authors: Colin Havenar-Daughton; Diane G Carnathan; Alba Torrents de la Peña; Matthias Pauthner; Bryan Briney; Samantha M Reiss; Jennifer S Wood; Kirti Kaushik; Marit J van Gils; Sandy L Rosales; Patricia van der Woude; Michela Locci; Khoa M Le; Steven W de Taeye; Devin Sok; Ata Ur Rasheed Mohammed; Jessica Huang; Sanjeev Gumber; AnaPatricia Garcia; Sudhir P Kasturi; Bali Pulendran; John P Moore; Rafi Ahmed; Grégory Seumois; Dennis R Burton; Rogier W Sanders; Guido Silvestri; Shane Crotty Journal: Cell Rep Date: 2016-11-22 Impact factor: 9.423
Authors: Kendall C Krebs; Meijuan Tian; Mohammed Asmal; Binhua Ling; Kenneth Nelson; Kenneth Henry; Richard Gibson; Yuejin Li; Weining Han; Robin J Shattock; Ronald S Veazey; Norman Letvin; Eric J Arts; Yong Gao Journal: AIDS Res Ther Date: 2016-11-25 Impact factor: 2.250