Literature DB >> 2573010

Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations.

R Markstein1, K A Stöckli, J C Reubi.   

Abstract

In homogenates of rat hippocampus and striatum, but not substantia nigra, somatostatin (SRIF) inhibits forskolin-activated adenylate cyclase in nanomolar concentrations. However, SRIF can also stimulate adenylate cyclase in micromolar concentrations in homogenates of rat hippocampus and substantia nigra. The SRIF octapeptide SMS 201-995 solely inhibits the forskolin-activated adenylate cyclase in the 3 preparations. These results suggest that the SRIF-specific stimulation of adenylate cyclase may be a functional correlate for the brain-specific SRIF receptor subpopulation, whereas the SRIF and SMS 201-995 inhibition of stimulated adenylate cyclase correlate with the SRIF receptor subpopulation present in brain and non-neuronal tissues.

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Year:  1989        PMID： 2573010     DOI： 10.1016/0304-3940(89)90321-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

1.  Neurotransmitter-mediated inhibition of post-mortem human brain adenylyl cyclase.

Authors:  A Garlind; C J Fowler; I Alafuzoff; B Winblad; R F Cowburn
Journal:  J Neural Transm Gen Sect       Date:  1992

2.  Somatostatin acts through G-proteins on dopaminergic adenylate cyclase in the caudate-putamen of the rat.

Authors:  A Moser; H Cramer
Journal:  Neurochem Res       Date:  1990-11       Impact factor: 3.996

3.  Activation of adenylate cyclase by human recombinant sst5 receptors expressed in CHO-K1 cells and involvement of Galphas proteins.

Authors:  A M Carruthers; A J Warner; A D Michel; W Feniuk; P P Humphrey
Journal:  Br J Pharmacol       Date:  1999-03       Impact factor: 8.739

Review 4.  Molecular pharmacology of somatostatin receptors.

Authors:  D Hoyer; H Lübbert; C Bruns
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

5.  Localization of somatostatin (SRIF) SSTR-1, SSTR-2 and SSTR-3 receptor mRNA in rat brain by in situ hybridization.

Authors:  J Pérez; M Rigo; K Kaupmann; C Bruns; K Yasuda; G I Bell; H Lübbert; D Hoyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-02       Impact factor: 3.000

6.  Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain.

Authors:  Catherine Videau; Ute Hochgeschwender; Hans Jürgen Kreienkamp; Miles B Brennan; Cécile Viollet; Dietmar Richter; Jacques Epelbaum
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-05-21       Impact factor: 3.000

7.  Somatostatin receptors in differentiated ovarian tumors.

Authors:  J C Reubi; U Horisberger; J G Klijn; J A Foekens
Journal:  Am J Pathol       Date:  1991-05       Impact factor: 4.307

8.  Somatostatin-binding sites on rat telencephalic astrocytes. Light- and electron-microscopic studies in vitro and in vivo.

Authors:  R Mentlein; C Buchholz; B Krisch
Journal:  Cell Tissue Res       Date:  1990-12       Impact factor: 5.249

9.  Operational characteristics of somatostatin receptors mediating inhibitory actions on rat locus coeruleus neurones.

Authors:  I P Chessell; M D Black; W Feniuk; P P Humphrey
Journal:  Br J Pharmacol       Date:  1996-04       Impact factor: 8.739
  9 in total

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