Literature DB >> 2572995

Effects of anxiolytic and anxiogenic drugs on exploratory activity in a simple model of anxiety in mice.

T Kilfoil1, A Michel, D Montgomery, R L Whiting.   

Abstract

Chlordizaepoxide, pentylenetrazole, phenobarbital, N-methyl-beta-carboline-3-carboxamide (FG-7142), buspirone and the novel serotonin3 receptor (5-HT3) antagonist, 3-tropanyl-indole-3-carboxylate (ICS 205-930), were examined in the two-compartment exploratory model (Crawley and Goodwin, 1980). The results indicated that, utilizing the time mice spend in the dark side of the apparatus as an index of anxiety, increased the sensitivity of the model and enabled both anxiolytic and anxiogenic agents to be detected.

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Year:  1989        PMID： 2572995     DOI： 10.1016/0028-3908(89)90188-3

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  14 in total

1.  Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice.

Authors:  Kiersten S Smith; Edward G Meloni; Karyn M Myers; Ashlee Van't Veer; William A Carlezon; Uwe Rudolph
Journal:  Psychopharmacology (Berl)       Date:  2010-10-05       Impact factor: 4.530

2.  Evidence that the amygdala is involved in the disinhibitory effects of 5-HT3 receptor antagonists.

Authors:  G A Higgins; B J Jones; N R Oakley; M B Tyers
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

3.  Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior.

Authors:  Shibani Mukherjee; Laurent Coque; Jun-Li Cao; Jaswinder Kumar; Sumana Chakravarty; Aroumougame Asaithamby; Ami Graham; Elizabeth Gordon; John F Enwright; Ralph J DiLeone; Shari G Birnbaum; Donald C Cooper; Colleen A McClung
Journal:  Biol Psychiatry       Date:  2010-06-29       Impact factor: 13.382

4.  Experimental anxiety and antidepressant drugs: the effects of moclobemide, a selective reversible MAO-A inhibitor, fluoxetine and imipramine in mice.

Authors:  L de Angelis
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996 Aug-Sep       Impact factor: 3.000

5.  The effects of acute and chronic psychological stress on bladder function in a rodent model.

Authors:  Ariana L Smith; Joanne Leung; Suny Kun; Rong Zhang; Iordanes Karagiannides; Shlomo Raz; Una Lee; Viktoriya Glovatscka; Charalabos Pothoulakis; Sylvie Bradesi; Emeran A Mayer; Larissa V Rodríguez
Journal:  Urology       Date:  2011-08-24       Impact factor: 2.649

6.  The behavioural properties of CI-988, a selective cholecystokininB receptor antagonist.

Authors:  L Singh; M J Field; J Hughes; R Menzies; R J Oles; C A Vass; G N Woodruff
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

7.  The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine.

Authors:  L Singh; M J Field; P Ferris; J C Hunter; R J Oles; R G Williams; G N Woodruff
Journal:  Psychopharmacology (Berl)       Date:  1996-09       Impact factor: 4.530

Review 8.  5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions.

Authors:  J E Barrett; K E Vanover
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  The benzodiazepine antagonist flumazenil blocks the effects of CCK receptor agonists and antagonists in the elevated plus-maze.

Authors:  P Chopin; M Briley
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

10.  Ondansetron improves cognitive performance in the Morris water maze spatial navigation task.

Authors:  D J Fontana; S E Daniels; C Henderson; R M Eglen; E H Wong
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530
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