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Literature DB >> 25729554

Structure activity relationship study of Mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity.

Penny J Beuning¹, George A O'Doherty¹, Sumit O Bajaj¹, Pei Shi¹.

Abstract

Ten members of the mezzettiaside family of natural products were synthesized and evaluated for anticancer and antibacterial activity. Complete anticancer (H460) and antibacterial (B. subtilis) activities for the ten natural products and four new analogues were found. Comparison to the cleistrioside and cleistetroside classes of natural products were made.

Entities: Chemical Disease Gene Species

Year: 2014 PMID： 25729554 PMCID： PMC4338990 DOI： 10.1039/C4MD00095A

Source DB: PubMed Journal: Medchemcomm ISSN： 2040-2503 Impact factor: 3.597

19 in total

1. De novo asymmetric synthesis of the mezzettiaside family of natural products via the iterative use of a dual B-/Pd-catalyzed glycosylation.

Authors: Sumit O Bajaj; Ehesan U Sharif; Novruz G Akhmedov; George A O'Doherty
Journal: Chem Sci Date: 2014-06 Impact factor: 9.825

2. Synthesis of several cleistrioside and cleistetroside natural products via a divergent de novo asymmetric approach.

Authors: Bulan Wu; Miaosheng Li; George A O'Doherty
Journal: Org Lett Date: 2010-11-01 Impact factor: 6.005

3. De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction.

Authors: Haibing Guo; George A O'Doherty
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

4. Genome and virulence determinants of high virulence community-acquired MRSA.

Authors: Tadashi Baba; Fumihiko Takeuchi; Makoto Kuroda; Harumi Yuzawa; Ken-ichi Aoki; Akio Oguchi; Yoshimi Nagai; Natsuko Iwama; Kazuyuki Asano; Timothy Naimi; Hiroko Kuroda; Longzhu Cui; Kenji Yamamoto; Keiichi Hiramatsu
Journal: Lancet Date: 2002-05-25 Impact factor: 79.321

5. De novo enantioselective syntheses of galacto-sugars and deoxy sugars via the iterative dihydroxylation of dienoate.

Authors: Md Moinuddin Ahmed; Bryan P Berry; Thomas J Hunter; Dennis J Tomcik; George A O'Doherty
Journal: Org Lett Date: 2005-02-17 Impact factor: 6.005

6. A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity.

Authors: Svetlana A Borisova; Sanjeeva R Guppi; Hak Joong Kim; Bulan Wu; John H Penn; Hung-Wen Liu; George A O'Doherty
Journal: Org Lett Date: 2010-10-19 Impact factor: 6.005

Structure activity relationship study of Mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity.

1. De novo asymmetric synthesis of the mezzettiaside family of natural products via the iterative use of a dual B-/Pd-catalyzed glycosylation.

2. Synthesis of several cleistrioside and cleistetroside natural products via a divergent de novo asymmetric approach.

3. De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction.

4. Genome and virulence determinants of high virulence community-acquired MRSA.

5. De novo enantioselective syntheses of galacto-sugars and deoxy sugars via the iterative dihydroxylation of dienoate.

6. A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity.

7. Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability.

8. De novo asymmetric synthesis of anthrax tetrasaccharide and related tetrasaccharide.

9. A palladium-catalyzed glycosylation reaction: the de novo synthesis of natural and unnatural glycosides.

10. De novo synthesis of oligosaccharides using a palladium-catalyzed glycosylation reaction.

Review 1. Recent advances in site-selective functionalization of carbohydrates mediated by organocatalysts.

2. Editorial to Special Issue-"Structure-Activity Relationships (SAR) of Natural Products".