Literature DB >> 25728278

MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway.

Changhe Hou1, Zibo Yang1, Yan Kang1, Ziji Zhang1, Ming Fu1, Aishan He1, Zhiqi Zhang2, Weiming Liao3.   

Abstract

Cartilage generation and degradation are regulated by miRNAs. Our previous study has shown altered expression of miR-193b in chondrogenic human adipose-derived mesenchymal stem cells (hADSCs). In the current study, we investigated the role of miR-193b in chondrogenesis and cartilage degradation. Luciferase reporter assays showed that miR-193b targeted seed sequences of the TGFB2 and TGFBR3 3'-UTRs. MiR-193b suppressed the expression of early chondrogenic markers in chondrogenic ATDC5 cells, and TNF-alpha expression in IL-1b-induced PMCs. In conclusion, MiR-193b may inhibit early chondrogenesis by targeting TGFB2 and TGFBR3, and may regulate inflammation by repressing TNF-alpha expression in inflamed chondrocytes.
Copyright © 2015. Published by Elsevier B.V.

Entities:  

Keywords:  Chondrogenesis; MiR-193b; Osteoarthritis; TGF-beta; TNF-alpha

Mesh：

Substances：

Year:  2015        PMID： 25728278     DOI： 10.1016/j.febslet.2015.02.017

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R.

Authors:  Bao-Feng Li; Ying Zhang; Jin Xiao; Fei Wang; Mei Li; Xiao-Ze Guo; Hui-Bin Xie; Hong Xia; Bei Chen
Journal:  Hum Cell       Date:  2017-08-09       Impact factor: 4.174

Review 2.  The role of microRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies.

Authors:  Maria Rosa Iaquinta; Carmen Lanzillotti; Chiara Mazziotta; Ilaria Bononi; Francesca Frontini; Elisa Mazzoni; Lucia Oton-Gonzalez; John Charles Rotondo; Elena Torreggiani; Mauro Tognon; Fernanda Martini
Journal:  Theranostics       Date:  2021-04-30       Impact factor: 11.556

Review 3.  Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis.

Authors:  Onju Ham; Chang Youn Lee; Ran Kim; Jihyun Lee; Sekyung Oh; Min Young Lee; Jongmin Kim; Ki-Chul Hwang; Lee-So Maeng; Woochul Chang
Journal:  Int J Mol Sci       Date:  2015-07-02       Impact factor: 5.923

4.  MicroRNA 193b-3p as a predictive biomarker of chronic kidney disease in patients undergoing radical nephrectomy for renal cell carcinoma.

Authors:  Francesco Trevisani; Michele Ghidini; Alessandro Larcher; Andrea Lampis; Hazel Lote; Paolo Manunta; Maria Teresa Sciarrone Alibrandi; Laura Zagato; Lorena Citterio; Giacomo Dell'Antonio; Cristina Carenzi; Giovambattista Capasso; Massimo Rugge; Paolo Rigotti; Roberto Bertini; Luciano Cascione; Alberto Briganti; Andrea Salonia; Fabio Benigni; Chiara Braconi; Matteo Fassan; Jens Claus Hahne; Francesco Montorsi; Nicola Valeri
Journal:  Br J Cancer       Date:  2016-11-01       Impact factor: 7.640

5.  Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway.

Authors:  Kaiming Wu; Zhenxian Zhao; Jun Ma; Jianhui Chen; Jianjun Peng; Shibin Yang; Yulong He
Journal:  Oncol Lett       Date:  2017-02-22       Impact factor: 2.967

Review 6.  Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications.

Authors:  Dana Elena Giza; Enrique Fuentes-Mattei; Marc David Bullock; Stefan Tudor; Matthew Joseph Goblirsch; Muller Fabbri; Florea Lupu; Sai-Ching Jim Yeung; Catalin Vasilescu; George Adrian Calin
Journal:  Cell Death Differ       Date:  2016-10-14       Impact factor: 15.828

Review 7.  Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments.

Authors:  Catherine Baugé; Karim Boumédiene
Journal:  Stem Cells Int       Date:  2015-07-09       Impact factor: 5.443

Review 8.  The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases.

Authors:  Emma Budd; Shona Waddell; María C de Andrés; Richard O C Oreffo
Journal:  Curr Mol Biol Rep       Date:  2017-10-23

9.  MiR-146b is down-regulated during the chondrogenic differentiation of human bone marrow derived skeletal stem cells and up-regulated in osteoarthritis.

Authors:  Emma Budd; María C de Andrés; Tilman Sanchez-Elsner; Richard O C Oreffo
Journal:  Sci Rep       Date:  2017-04-24       Impact factor: 4.379

10.  MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression.

Authors:  Weishen Chen; Puyi Sheng; Zhiyu Huang; Fangang Meng; Yan Kang; Guangxin Huang; Zhiqi Zhang; Weiming Liao; Ziji Zhang
Journal:  Int J Mol Sci       Date:  2016-08-23       Impact factor: 5.923
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