Kangkang Yan1, Xuejing Xu1, Xiaodong Liu2, Xikui Wang3, Shucheng Hua4, Chunpeng Wang5, Xin Liu1. 1. Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, Jilin, China. 2. Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, China. 3. Department of Statistics, University of Manitoba, Winnipeg, Canada. 4. The First Hospital of Jilin University, Changchun, China. 5. School of Mathematics and Statistics, Northeast Normal University, Changchun, Jilin, China.
Abstract
BACKGROUND: Although genetic and environmental factors are considered to be the main causes of acute lymphoblastic leukemia, the associations between maternal factors during pregnancy and the childhood ALL is still unclear. PROCEDURE: In this study, meta-analysis was used. Medline, PubMed, and Web of Science were searched. The result was assessed based on pooled odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: The pooled ORs showed that there were associations between childhood ALL and the birth order (The first vs others, OR = 1.08, 95%CI = 1.00-1.16), the education of pregnant woman (>high school vs ≤ high school, OR = 0.82, 95%CI = 0.77-0.86), smoking (Ever vs never, OR = 1.10, 95%CI = 1.02-1.19). CONCLUSIONS: Our meta-analysis showed that there were important associations between childhood ALL and the birth order, the education of pregnant woman, smoking.
BACKGROUND: Although genetic and environmental factors are considered to be the main causes of acute lymphoblastic leukemia, the associations between maternal factors during pregnancy and the childhood ALL is still unclear. PROCEDURE: In this study, meta-analysis was used. Medline, PubMed, and Web of Science were searched. The result was assessed based on pooled odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: The pooled ORs showed that there were associations between childhood ALL and the birth order (The first vs others, OR = 1.08, 95%CI = 1.00-1.16), the education of pregnant woman (>high school vs ≤ high school, OR = 0.82, 95%CI = 0.77-0.86), smoking (Ever vs never, OR = 1.10, 95%CI = 1.02-1.19). CONCLUSIONS: Our meta-analysis showed that there were important associations between childhood ALL and the birth order, the education of pregnant woman, smoking.
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