Han Boon Oh1, Vaishnavi Muthu1, Zubin J Daruwalla2, Shir Ying Lee3, Evelyn S Koay4, Paul A Tambyah5. 1. University Surgical Cluster, Singapore. 2. Department of Orthopedic Surgery, Singapore. 3. Department of Hematology-Oncology, Singapore. 4. Department of Laboratory Medicine, Singapore. 5. Department of Infectious Diseases, National University Health System, Singapore.
Abstract
BACKGROUND: Blood-borne infections remain a risk of blood transfusions. While routine screening of donated blood products has greatly reduced the risk of human immunodeficiency virus, hepatitis B, and hepatitis C transmission, arboviruses such as dengue, chikungunya, and the West Nile virus remain significant risks especially during outbreaks. CASE REPORT: We report a rare case of dengue documented to be acquired through a blood transfusion, which resulted in severe thrombocytopenia prolonging admission in hospital in a neurosurgical patient. RESULTS: The donor of one of the units of red blood cells presented with dengue fever 2 days after donating. Sanger sequencing confirmed DENV-2 (dengue virus, Serotype 2) in both the donor and the patient samples and showed 100% nucleotide sequence identity between the two viruses, confirming transfusion-transmitted dengue infection. CONCLUSION: This case highlights the importance of arboviral screening of donor blood, especially for populations in endemic areas during outbreaks.
BACKGROUND: Blood-borne infections remain a risk of blood transfusions. While routine screening of donated blood products has greatly reduced the risk of human immunodeficiency virus, hepatitis B, and hepatitis C transmission, arboviruses such as dengue, chikungunya, and the West Nile virus remain significant risks especially during outbreaks. CASE REPORT: We report a rare case of dengue documented to be acquired through a blood transfusion, which resulted in severe thrombocytopenia prolonging admission in hospital in a neurosurgical patient. RESULTS: The donor of one of the units of red blood cells presented with dengue fever 2 days after donating. Sanger sequencing confirmed DENV-2 (dengue virus, Serotype 2) in both the donor and the patient samples and showed 100% nucleotide sequence identity between the two viruses, confirming transfusion-transmitted dengue infection. CONCLUSION: This case highlights the importance of arboviral screening of donor blood, especially for populations in endemic areas during outbreaks.
Authors: Ester C Sabino; Paula Loureiro; Maria Esther Lopes; Ligia Capuani; Christopher McClure; Dhuly Chowdhury; Claudia Di-Lorenzo-Oliveira; Lea C Oliveira; Jeffrey M Linnen; Tzong-Hae Lee; Thelma Gonçalez; Donald Brambilla; Steve Kleinman; Michael P Busch; Brian Custer Journal: J Infect Dis Date: 2015-06-08 Impact factor: 5.226
Authors: Michael P Busch; Ester C Sabino; Donald Brambilla; Maria Esther Lopes; Ligia Capuani; Dhuly Chowdhury; Christopher McClure; Jeffrey M Linnen; Harry Prince; Graham Simmons; Tzong-Hae Lee; Steven Kleinman; Brian Custer Journal: J Infect Dis Date: 2016-04-01 Impact factor: 5.226
Authors: Germán Añez; Daniel A R Heisey; Caren Chancey; Rafaelle C G Fares; Luz M Espina; Kátia P R Souza; Andréa Teixeira-Carvalho; David E Krysztof; Gregory A Foster; Susan L Stramer; Maria Rios Journal: PLoS Negl Trop Dis Date: 2016-02-12