Takashi Nomura1, Yuichi Inoue2, Tatsuo Kagimura3, Masayoshi Kusumi1, Kenji Nakashima1. 1. Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Tottori, Japan. 2. Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan. 3. Translational Research Informatics Center, Hyogo, Japan.
Abstract
AIMS: In order to evaluate the validity of the REM Sleep Behavior Disorder (RBD) Screening Questionnaire (RBDSQ) as a screening tool for RBD in a general population setting, we conducted a validation study using residents of a rural community. METHODS: We sent questionnaires that included the RBDSQ to 2631 eligible adult residents in the town of Daisen, Japan. RESULTS: Of those residents, 1572 participants (59.7%) gave complete answers to the RBDSQ. Among them, 179 participants (11.4%) scored ≥5 points on the questionnaire; an additional 149 participants scoring ≤4 points were randomly selected for further telephone interview. Based on obtained results, nine participants (0.57%) were judged as having probable RBD. Receiver-operator curve analysis revealed that a total score of 6 points on the RBDSQ represented the best cut-off value for detecting probable RBD (sensitivity: 100%; specificity: 73.0%). Analysis based on the item response theory revealed that items 1, 4, 6-1, 7, and 8 had lower difficulty than the remaining items, suggesting that these items are more essential in the screening for probable RBD. CONCLUSIONS: The present study revealed that a score of 6 points on the RBDSQ could be used as a cut-off value for the screening of probable RBD in the general population. Evaluation of the distribution of positive items might be helpful for identifying the intensity of a person's RBD symptoms.
AIMS: In order to evaluate the validity of the REM Sleep Behavior Disorder (RBD) Screening Questionnaire (RBDSQ) as a screening tool for RBD in a general population setting, we conducted a validation study using residents of a rural community. METHODS: We sent questionnaires that included the RBDSQ to 2631 eligible adult residents in the town of Daisen, Japan. RESULTS: Of those residents, 1572 participants (59.7%) gave complete answers to the RBDSQ. Among them, 179 participants (11.4%) scored ≥5 points on the questionnaire; an additional 149 participants scoring ≤4 points were randomly selected for further telephone interview. Based on obtained results, nine participants (0.57%) were judged as having probable RBD. Receiver-operator curve analysis revealed that a total score of 6 points on the RBDSQ represented the best cut-off value for detecting probable RBD (sensitivity: 100%; specificity: 73.0%). Analysis based on the item response theory revealed that items 1, 4, 6-1, 7, and 8 had lower difficulty than the remaining items, suggesting that these items are more essential in the screening for probable RBD. CONCLUSIONS: The present study revealed that a score of 6 points on the RBDSQ could be used as a cut-off value for the screening of probable RBD in the general population. Evaluation of the distribution of positive items might be helpful for identifying the intensity of a person's RBD symptoms.
Authors: Ambra Stefani; Philipp Mahlknecht; Klaus Seppi; Michael Nocker; Katherina J Mair; Anna Hotter; Heike Stockner; Johann Willeit; Stefan Kiechl; Gregor Rungger; Arno Gasperi; Werner Poewe; Birgit Högl Journal: Mov Disord Clin Pract Date: 2016-11-01