Literature DB >> 25727852

p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis.

Maria del Pilar Camacho Leal1, Marianna Sciortino1, Giusy Tornillo2, Shana Colombo1, Paola Defilippi1, Sara Cabodi3.   

Abstract

BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell-extracellular matrix (ECM) adhesion and growth factor stimulation cascades during normal development and disease in various biological models. In this review we will specifically discuss the more recent data on the contribution of p130Cas/BCAR1 in the regulation of tissue homeostasis and its potential implications in pathological conditions.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Adaptor protein; Cancer; Cell motility; Development; Intracellular signaling pathways; p130Cas/BCAR1

Mesh：

Substances：

Year:  2015        PMID： 25727852      PMCID： PMC6639054          DOI： 10.1016/j.gene.2015.02.027

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  62 in total

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Authors:  N Hamid; A Gustavsson; K Andersson; K McGee; C Persson; C E Rudd; M Fällman
Journal:  Microb Pathog       Date:  1999-10       Impact factor: 3.738

Review 2.  Functions of the adapter protein Cas: signal convergence and the determination of cellular responses.

Authors:  A H Bouton; R B Riggins; P J Bruce-Staskal
Journal:  Oncogene       Date:  2001-10-01       Impact factor: 9.867

3.  Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 regulator of kinase (Crk) proteins.

Authors:  Jianjun Sun; Joseph T Barbieri
Journal:  J Biol Chem       Date:  2003-06-13       Impact factor: 5.157

4.  Activation of a signaling cascade by cytoskeleton stretch.

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Journal:  Dev Cell       Date:  2004-11       Impact factor: 12.270

5.  The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions.

Authors:  Sharmilla D Bargon; Peter W Gunning; Geraldine M O'Neill
Journal:  Biochim Biophys Acta       Date:  2005-11-14

Review 6.  p130Cas: a versatile scaffold in signaling networks.

Authors:  Paola Defilippi; Paola Di Stefano; Sara Cabodi
Journal:  Trends Cell Biol       Date:  2006-04-03       Impact factor: 20.808

7.  CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells.

Authors:  C L Weidow; D S Black; J B Bliska; A H Bouton
Journal:  Cell Microbiol       Date:  2000-12       Impact factor: 3.715

8.  Uncoupling Crk signal transduction by Pseudomonas exoenzyme T.

Authors:  Qing Deng; Jianjun Sun; Joseph T Barbieri
Journal:  J Biol Chem       Date:  2005-08-25       Impact factor: 5.157

9.  Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration.

Authors:  Xin A Zhang; Bo He; Bin Zhou; Li Liu
Journal:  J Biol Chem       Date:  2003-05-08       Impact factor: 5.157

10.  The prognostic value of BCAR1 in patients with primary breast cancer.

Authors:  Lambert C J Dorssers; Nicolai Grebenchtchikov; Arend Brinkman; Maxime P Look; Simone P J van Broekhoven; Danielle de Jong; Harry A Peters; Henk Portengen; Marion E Meijer-van Gelder; Jan G M Klijn; Doorlene T H van Tienoven; Anneke Geurts-Moespot; Paul N Span; John A Foekens; Fred C G J Sweep
Journal:  Clin Cancer Res       Date:  2004-09-15       Impact factor: 12.531
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  15 in total

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3.  A meta-analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma.

Authors:  Daniel Ortega-Bernal; Claudia H González-De La Rosa; Elena Arechaga-Ocampo; Miguel Angel Alvarez-Avitia; Nora Sobrevilla Moreno; Claudia Rangel-Escareño
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Journal:  Biochemistry       Date:  2018-02-06       Impact factor: 3.162

5.  High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer.

Authors:  Asmus Heumann; Nina Heinemann; Claudia Hube-Magg; Dagmar S Lang; Katharina Grupp; Martina Kluth; Sarah Minner; Christina Möller-Koop; Markus Graefen; Hans Heinzer; Maria Christina Tsourlakis; Waldemar Wilczak; Corinna Wittmer; Frank Jacobsen; Hartwig Huland; Ronald Simon; Thorsten Schlomm; Guido Sauter; Stefan Steurer; Patrick Lebok; Andrea Hinsch
Journal:  BMC Cancer       Date:  2018-01-05       Impact factor: 4.430

6.  Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation.

Authors:  Maria Del Pilar Camacho Leal; Andrea Costamagna; Beatrice Tassone; Stefania Saoncella; Matilde Simoni; Dora Natalini; Aurora Dadone; Marianna Sciortino; Emilia Turco; Paola Defilippi; Enzo Calautti; Sara Cabodi
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7.  Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy.

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Journal:  Nat Commun       Date:  2019-09-19       Impact factor: 14.919

8.  Identification of adhesion-associated DNA methylation patterns in the peripheral nervous system.

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9.  Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma.

Authors:  Edward Britton; Connor Rogerson; Shaveta Mehta; Yaoyong Li; Xiaodun Li; Rebecca C Fitzgerald; Yeng S Ang; Andrew D Sharrocks
Journal:  PLoS Genet       Date:  2017-08-31       Impact factor: 5.917

10.  BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.

Authors:  Chun-Guo Mao; Sha-Sha Jiang; Cheng Shen; Tan Long; Hua Jin; Qun-You Tan; Bo Deng
Journal:  Thorac Cancer       Date:  2020-10-01       Impact factor: 3.500
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