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Literature DB >> 25727479

The role of Ca(2+) activated Cl(-) channels in blood pressure control.

Vladimir V Matchkov¹, Donna M Boedtkjer¹, Christian Aalkjaer².

Abstract

Ca(2+)-activated Cl(-) channels (CaCCs) have numerous functions in the body and are potential players in the control of blood pressure. The CaCCs represent a heterologous group including at least two protein families; TMEM16 and bestrophins. CaCCs expression has been shown in the kidney, the heart and blood vessels. Agonist-stimulated Ca(2+)-activated Cl(-) current is important for secretion in kidney epithelia, generation of a repolarizing current in the heart and amplification of excitation-contraction coupling in vascular smooth muscle cells. Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias. This review discusses recent advances in studies concerning the role of CaCC for blood pressure control with focus on the kidney, the heart and blood vessels.

Entities: Chemical Disease Gene

Mesh：

Substances：
Chloride Channels
Calcium

Year: 2015 PMID： 25727479 DOI： 10.1016/j.coph.2015.02.003

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

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Cited

10 in total

1. Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.

Authors: Silvia Cruz-Rangel; José J De Jesús-Pérez; Juan A Contreras-Vite; Patricia Pérez-Cornejo; H Criss Hartzell; Jorge Arreola
Journal: J Physiol Date: 2015-12-07 Impact factor: 5.182

Review 2. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

Authors: Nathan R Tykocki; Erika M Boerman; William F Jackson
Journal: Compr Physiol Date: 2017-03-16 Impact factor: 9.090

Review 3. Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.

Authors: F V Brozovich; C J Nicholson; C V Degen; Yuan Z Gao; M Aggarwal; K G Morgan
Journal: Pharmacol Rev Date: 2016-04 Impact factor: 25.468

4. Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16A.

Authors: Silvia Cruz-Rangel; José J De Jesús-Pérez; Iván A Aréchiga-Figueroa; Aldo A Rodríguez-Menchaca; Patricia Pérez-Cornejo; H Criss Hartzell; Jorge Arreola
Journal: J Physiol Date: 2017-01-03 Impact factor: 5.182

5. Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice.

Authors: Michele Celestino; Valeria Balmaceda Valdez; Paola Brun; Ignazio Castagliuolo; Carla Mucignat-Caretta
Journal: Sci Rep Date: 2021-01-12 Impact factor: 4.379

Review 6. Molecular mechanisms of activation and regulation of ANO1-Encoded Ca²⁺-Activated Cl^- channels.

Authors: M B Hawn; E Akin; H C Hartzell; I A Greenwood; N Leblanc
Journal: Channels (Austin) Date: 2021-12 Impact factor: 2.581

7. The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia.

Authors: Nils Korte; Zeki Ilkan; Claire L Pearson; Thomas Pfeiffer; Prabhav Singhal; Jason R Rock; Huma Sethi; Dipender Gill; David Attwell; Paolo Tammaro
Journal: J Clin Invest Date: 2022-05-02 Impact factor: 19.456

The role of Ca(2+) activated Cl(-) channels in blood pressure control.

1. Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.

Review 2. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

Review 3. Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.

4. Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16A.

5. Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice.

Review 6. Molecular mechanisms of activation and regulation of ANO1-Encoded Ca²⁺-Activated Cl^- channels.

7. The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia.

Review 8. Vascular smooth muscle contraction in hypertension.

9. Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2.

10. A paradoxical increase of force development in saphenous and tail arteries from heterozygous ANO1 knockout mice.

The role of Ca(2+) activated Cl(-) channels in blood pressure control.

1. Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.

Review 2. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

Review 3. Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.

4. Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16A.

5. Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice.

Review 6. Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels.

7. The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia.

Review 8. Vascular smooth muscle contraction in hypertension.

9. Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2.

10. A paradoxical increase of force development in saphenous and tail arteries from heterozygous ANO1 knockout mice.

Review 6. Molecular mechanisms of activation and regulation of ANO1-Encoded Ca²⁺-Activated Cl^- channels.