Antonio Gradillas-García1, Julia Álvarez2, José Antonio Rubio3, Francisco J de Abajo4. 1. Medicina de Familia y Comunitaria, Centro de Salud Luis Vives , Alcalá de Henares, España. Electronic address: antoniogradillas@yahoo.es. 2. Departamento de Endocrinología y Nutrición, Hospital Universitario Príncipe de Asturias , Alcalá de Henares, España; Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Alcalá de Henares, España. 3. Departamento de Endocrinología y Nutrición, Hospital Universitario Príncipe de Asturias , Alcalá de Henares, España; Departamento de Ciencias Biomédicas, Universidad de Alcalá, Alcalá de Henares, España. 4. Departamento de Ciencias Biomédicas, Universidad de Alcalá, Alcalá de Henares, España; Unidad de Farmacología Clínica, Hospital Universitario Príncipe de Asturias, , Alcalá de Henares, España.
Abstract
BACKGROUNDS AND OBJECTIVE: Previous studies have suggested an association between MS and vitamin D deficiency, but data are not conclusive. This study was intended to find out if metabolic syndrome, according to the 2009 IDF/AHA/NHLBI, is associated to the presence of vitamin D deficiency. MATERIAL AND METHODS: A cross-sectional study was conducted on a sample of 326 subjects aged 18 years or older, recruited from a health center in Alcalá de Henares. Participants underwent an interview and a standardized clinical examination. In a second visit, blood tests were performed in 255 subjects to quantify serum levels of 25-hydroxyvitamin D (25 OH-VitD) and different laboratory parameters associated to MS. The association between vitamin D deficiency and metabolic syndrome (and each of its components) was examined. RESULTS: In the study population, MS prevalence was 36.1% and prevalence of vitamin D deficiency (25 OH-Vit D<20 ng/mL) was 56.3%. MS was more common in the group of patients with vitamin D deficiency (43.4%) than in the group with no deficiency (26.8%, P=.006), with an estimated prevalence ratio of 1.62 (95% CI: 1.13-2.31). Adjustment for age, sex, and body mass index did not change such association. CONCLUSIONS: There is a significant association between vitamin D deficiency and MS. Both conditions are highly prevalent in our population.
BACKGROUNDS AND OBJECTIVE: Previous studies have suggested an association between MS and vitamin D deficiency, but data are not conclusive. This study was intended to find out if metabolic syndrome, according to the 2009 IDF/AHA/NHLBI, is associated to the presence of vitamin D deficiency. MATERIAL AND METHODS: A cross-sectional study was conducted on a sample of 326 subjects aged 18 years or older, recruited from a health center in Alcalá de Henares. Participants underwent an interview and a standardized clinical examination. In a second visit, blood tests were performed in 255 subjects to quantify serum levels of 25-hydroxyvitamin D (25 OH-VitD) and different laboratory parameters associated to MS. The association between vitamin D deficiency and metabolic syndrome (and each of its components) was examined. RESULTS: In the study population, MS prevalence was 36.1% and prevalence of vitamin D deficiency (25 OH-Vit D<20 ng/mL) was 56.3%. MS was more common in the group of patients with vitamin D deficiency (43.4%) than in the group with no deficiency (26.8%, P=.006), with an estimated prevalence ratio of 1.62 (95% CI: 1.13-2.31). Adjustment for age, sex, and body mass index did not change such association. CONCLUSIONS: There is a significant association between vitamin D deficiency and MS. Both conditions are highly prevalent in our population.
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