Uwe Wollina 1 , Alberto Goldman Show Affiliations »
Abstract
INTRODUCTION: Facial esthetics are important for self-esteem. Undesired submental fat (SMF) deposits lead to an unappealing submental profile associated with aging and overweight. Compound ATX-101 is a proprietary formulation of purified synthetic deoxycholic acid for pharmacological submental contouring. Review areas covered: This reviews covers anatomy of SMF, biochemistry of deoxycholic acid related to adipose tissue and tissue response to injection of ATX-101. Data from clinical trials were analyzed for efficacy and safety. METHODOLOGY: Published studies using PubMed(©) database 2000 - 2014 have been analyzed. The terms 'deoxycholate', 'deoxycholic acid', 'ATX-101' and 'injection lipolysis' were used. RESULTS: Deoxycholic acid causes adipocyte breakdown and an inflammatory tissue reaction leading to fat cell reduction and limited fibrosis. Four large clinical Phase III trials demonstrated efficacy of ATX-101 in reduction of SMF measured by validated scales and objective measurements. Patients reported improved psychological features and feeling. Adverse effects were mild and temporary. EXPERT OPINION: Adipocytolysis of SMF by ATX-101 is an important step forward to the development of approved drugs for reduction of localized fat pads. This could become a growing market.
INTRODUCTION: Facial esthetics are important for self-esteem. Undesired submental fat (SMF) deposits lead to an unappealing submental profile associated with aging and overweight. Compound ATX-101 is a proprietary formulation of purified synthetic deoxycholic acid for pharmacological submental contouring. Review areas covered: This reviews covers anatomy of SMF, biochemistry of deoxycholic acid related to adipose tissue and tissue response to injection of ATX-101 . Data from clinical trials were analyzed for efficacy and safety. METHODOLOGY: Published studies using PubMed(©) database 2000 - 2014 have been analyzed. The terms 'deoxycholate ', 'deoxycholic acid ', 'ATX-101 ' and 'injection lipolysis' were used. RESULTS: Deoxycholic acid causes adipocyte breakdown and an inflammatory tissue reaction leading to fat cell reduction and limited fibrosis . Four large clinical Phase III trials demonstrated efficacy of ATX-101 in reduction of SMF measured by validated scales and objective measurements. Patients reported improved psychological features and feeling. Adverse effects were mild and temporary. EXPERT OPINION: Adipocytolysis of SMF by ATX-101 is an important step forward to the development of approved drugs for reduction of localized fat pads. This could become a growing market.
Entities: Chemical
Disease
Species
Keywords:
ATX-101; deoxycholic acid; injection adipocytolysis; submental fat
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Year: 2015
PMID： 25724831 DOI： 10.1517/14656566.2015.1019465
Source DB: PubMed Journal: Expert Opin Pharmacother ISSN： 1465-6566 Impact factor: 3.889