Literature DB >> 25724443

Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats.

Xing Meng1, Hui Pei2, Chao Lan2.   

Abstract

Icariin, a plant-derived flavonoid, has multiple beneficial actions on the cardiovascular system. The current study investigated whether icariin postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. In in vivo rat model of myocardial ischemia/reperfusion, we found that postconditioning with icariin significantly reduced myocardial infarct size, serum level of TNF-α and IL-10, TNF-α and IL-10 expression, and apoptosis. Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002.

Entities:  

Keywords:  Icariin; Myocardial ischemia/reperfusion; PI3K/Akt

Mesh：

Substances：

Year:  2015        PMID： 25724443     DOI： 10.1007/s12013-015-0669-6

Source DB:  PubMed          Journal:  Cell Biochem Biophys        ISSN： 1085-9195            Impact factor:   2.194


  10 in total

1.  Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage.

Authors:  Bing Wu; Jian-Yu Feng; Li-Ming Yu; Yan-Chun Wang; Yong-Qing Chen; Yan Wei; Jin-Song Han; Xiao Feng; Yu Zhang; Shou-Yin Di; Zhi-Qiang Ma; Chong-Xi Fan; Xiao-Qin Ha
Journal:  Br J Pharmacol       Date:  2018-09-21       Impact factor: 8.739

Review 2.  Molecular mechanisms regulating the pharmacological actions of icariin with special focus on PI3K-AKT and Nrf-2 signaling pathways.

Authors:  Aanchal Verma; Kritika Aggarwal; Ritik Agrawal; Kajal Pradhan; Ahsas Goyal
Journal:  Mol Biol Rep       Date:  2022-08-08       Impact factor: 2.742

3.  [Icariin alleviates lipid peroxidation after spinal cord injury in rats].

Authors:  Xian-Sheng Ren; Wei Ding; Xiao-Yu Yang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2018-06-20

Review 4.  The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II.

Authors:  Meixia Chen; Jinfeng Wu; Qingli Luo; Shuming Mo; Yubao Lyu; Ying Wei; Jingcheng Dong
Journal:  Nutrients       Date:  2016-09-13       Impact factor: 5.717

5.  Icariin Prevents H2O2-Induced Apoptosis via the PI3K/Akt Pathway in Rat Nucleus Pulposus Intervertebral Disc Cells.

Authors:  Xiangyu Deng; Sheng Chen; Dong Zheng; Zengwu Shao; Hang Liang; Hongzhi Hu
Journal:  Evid Based Complement Alternat Med       Date:  2017-04-27       Impact factor: 2.629

6.  Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response.

Authors:  Miriam Scicchitano; Cristina Carresi; Saverio Nucera; Stefano Ruga; Jessica Maiuolo; Roberta Macrì; Federica Scarano; Francesca Bosco; Rocco Mollace; Antonio Cardamone; Anna Rita Coppoletta; Lorenza Guarnieri; Maria Caterina Zito; Irene Bava; Luca Cariati; Marta Greco; Daniela Patrizia Foti; Ernesto Palma; Micaela Gliozzi; Vincenzo Musolino; Vincenzo Mollace
Journal:  Nutrients       Date:  2021-11-14       Impact factor: 5.717

7.  Icariin inhibits hypoxia/reoxygenation-induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO-1 signaling pathway.

Authors:  Xiu-Juan Liu; Yan-Fei Lv; Wen-Zhu Cui; Yan Li; Yang Liu; Yi-Tao Xue; Feng Dong
Journal:  FEBS Open Bio       Date:  2021-09-27       Impact factor: 2.693

Review 8.  Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?

Authors:  Cong Chen; Lin-Tong Yu; Bai-Ru Cheng; Jiang-Lin Xu; Yun Cai; Jia-Lin Jin; Ru-Li Feng; Long Xie; Xin-Yan Qu; Dong Li; Jing Liu; Yan Li; Xiao-Yun Cui; Jin-Jin Lu; Kun Zhou; Qian Lin; Jie Wan
Journal:  Front Cardiovasc Med       Date:  2022-02-17

9.  Synthesis and evaluation of 99mTc-DOTA-ARA-290 as potential SPECT tracer for targeting cardiac ischemic region.

Authors:  Naser Mohtavinejad; Maliheh Hajiramezanali; Mehdi Akhlaghi; Ahmad Bitarafan-Rajabi; Nazila Gholipour
Journal:  Iran J Basic Med Sci       Date:  2021-11       Impact factor: 2.699

10.  Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to Improve Mitochondrial Dysfunction.

Authors:  Tingjuan Ni; Na Lin; Xingxiao Huang; Wenqiang Lu; Zhenzhu Sun; Jie Zhang; Hui Lin; Jufang Chi; Hangyuan Guo
Journal:  Front Pharmacol       Date:  2020-03-19       Impact factor: 5.810
  10 in total

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