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Literature DB >> 25724404

A simple, semi-deterministic approximation to the distribution of selective sweeps in large populations.

Abstract

In large populations, the distribution of the trajectory of allele frequencies under selection and genetic drift approaches a semi-deterministic behavior: a deterministic trajectory started and ended at stochastic boundary values. This provides simple yet accurate approximations for the distribution of allelic frequencies over time (conditional on fixation), and of extinction and fixation times, for both hard and soft sweeps, and under arbitrary inbreeding and dominance.

Keywords: Feller diffusion; Fixation time; Genetic drift; Selection; Selective sweep; Wright–Fisher diffusion

Mesh：

Year: 2015 PMID： 25724404 DOI： 10.1016/j.tpb.2015.01.004

Source DB: PubMed Journal: Theor Popul Biol ISSN： 0040-5809 Impact factor: 1.570

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Cited

9 in total

A simple, semi-deterministic approximation to the distribution of selective sweeps in large populations.

1. The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection.

2. Selective Sweep at a QTL in a Randomly Fluctuating Environment.

3. Genetic Signatures of Evolutionary Rescue by a Selective Sweep.

4. Time to fixation in changing environments.

5. What can be observed in real time PCR and when does it show?

6. Inferring Fitness Effects from Time-Resolved Sequence Data with a Delay-Deterministic Model.

7. On the establishment of a mutant.

8. Phenotypic but no genetic adaptation in zooplankton 24 years after an abrupt +10°C climate change.

9. Selective Sweeps Under Dominance and Inbreeding.