| Literature DB >> 25724309 |
Xianghua Zeng1, Cheng Xu1, Dengming He2, Huiyan Zhang1, Jie Xia1, Dairong Shi1, Lingjun Kong1, Xiaoqin He1, Yuming Wang3.
Abstract
Hepatic inflammation may affect the performance of FibroScan. This prospective study investigated the influence of hepatic inflammation on liver stiffness measurement (LSM) values by assessing FibroScan and liver biopsy findings in 325 patients with chronic hepatitis B. Liver fibrosis and inflammation were classified into five stages (S0-S4) and grades (G0-G4) according to the Scheuer scoring system. LSM values were correlated with fibrosis stage and inflammation grade (r = 0.479, p < 0.001, and r = 0.522, p < 0.001, respectively). Although LSM values increased in parallel with inflammation grade, no significant differences were found between patients with significant fibrosis (S2-S4) (p > 0.05). For inflammation grades G0, G1, G2 and G3, areas under receiver operating characteristic curves of FibroScan for significant fibrosis were 0.8267 (p < 0.001), 0.6956 (p < 0.001), 0.709 (p = 0.0012) and 0.6947 (p = 0.137), respectively. Inflammation has a significant influence on LSM values in patients with chronic hepatitis B with mild fibrosis, but not in those with significant fibrosis.Entities:
Keywords: Chronic hepatitis B; FibroScan; Inflammation; Liver stiffness measurement; Significant liver fibrosis
Mesh：
Year: 2015 PMID： 25724309 DOI： 10.1016/j.ultrasmedbio.2015.01.011
Source DB: PubMed Journal: Ultrasound Med Biol ISSN： 0301-5629 Impact factor: 2.998