Amrallah A Mohammed1, Abdullah S Al-Zahrani2, Hafez M Ghanem2, Mian U Farooq3, Amr M El Saify2, Hani M El-Khatib2. 1. Oncology Center, King Abdullah Medical City-Holy Capital, Saudi Arabia; Medical Oncology Department, Faculty of Medicine, Zagazig University, Egypt. Electronic address: amrallaabdelmoneem@yahoo.com. 2. Oncology Center, King Abdullah Medical City-Holy Capital, Saudi Arabia. 3. Strategic Planning Department, King Abdullah Medical City-Holy Capital, Saudi Arabia.
Abstract
BACKGROUND: This study evaluates the use of palliative chemotherapy (PCT) and possible associated factors at the end of life. METHOD: The study includes all advanced non hematological cancer patients who died in the King Abdullah Medical City during the period from January 2011 to April 2014. Demographic and disease features were registered. RESULTS: 420 patients were included in the study, median age 62 years (range 17-108); 52% female and 48% male. 87.4% of patients were Saudis and 12.6% non Saudis. 124 (29.5%) patients received PCT at the last month before death (LM-PCT): 21.8%, 22.6% and 55.6% within one, two and four weeks of death, respectively. Place of death (critical care vs. regular ward) and mode of admission (ER vs. OPD vs. Transferred) had a strong association with LM-PCT (p<0.0001, ϕ=0.35) and (p<0.0001, V=0.43), respectively. There was a gradual increase in the number of patients receiving LM-PCT from January 2011 to April 2014; 15.3%, 28.2%, 37.1% and 19.4%, respectively. CONCLUSION: In our center; at the end of life, there is a gradual increase in the number of patients receiving chemotherapy which significantly increased cancer patients' odds without clear predictive factors associated with its use, which calls into question the benefits of PCT in terminally ill cancer patients.
BACKGROUND: This study evaluates the use of palliative chemotherapy (PCT) and possible associated factors at the end of life. METHOD: The study includes all advanced non hematological cancerpatients who died in the King Abdullah Medical City during the period from January 2011 to April 2014. Demographic and disease features were registered. RESULTS: 420 patients were included in the study, median age 62 years (range 17-108); 52% female and 48% male. 87.4% of patients were Saudis and 12.6% non Saudis. 124 (29.5%) patients received PCT at the last month before death (LM-PCT): 21.8%, 22.6% and 55.6% within one, two and four weeks of death, respectively. Place of death (critical care vs. regular ward) and mode of admission (ER vs. OPD vs. Transferred) had a strong association with LM-PCT (p<0.0001, ϕ=0.35) and (p<0.0001, V=0.43), respectively. There was a gradual increase in the number of patients receiving LM-PCT from January 2011 to April 2014; 15.3%, 28.2%, 37.1% and 19.4%, respectively. CONCLUSION: In our center; at the end of life, there is a gradual increase in the number of patients receiving chemotherapy which significantly increased cancerpatients' odds without clear predictive factors associated with its use, which calls into question the benefits of PCT in terminally ill cancerpatients.
Authors: Tarek Assi; Elie El Rassy; Samer Tabchi; Toni Ibrahim; Tania Moussa; Ralph Chebib; Fadi El Karak; Fadi Farhat; Georges Chahine; Fadi Nasr; Marwan Ghosn; Joseph Kattan Journal: Support Care Cancer Date: 2015-09-21 Impact factor: 3.603
Authors: Andrea A Martoni; Barbara Melotti; Claudia Degli Esposti; Vita Mutri; Giorgio Lelli; Silvia Ansaloni; Erico Piva; Elena Strocchi; Franco Pannuti Journal: ESMO Open Date: 2017-03-14