BACKGROUND: Elevated urine Mg excretion and its correlation with histological damage in tubulo-interstitial nephropathy (TIN) were reported. Here we investigated the clinical significance of the fractional excretion of Mg (FEMg) for the prediction of TIN. METHODS: We enrolled and assessed 94 adult patients with various renal diseases diagnosed principally by renal biopsy. RESULTS: Our stratified analysis based on the value of the conventional TIN parameter N-acetylglucosaminidase (NAG) excretion showed that the high-NAG index group (more than median value of NAG-to-Cr ratio, n = 47) demonstrated significantly high FEMg values (p = 0.017). A univariate analysis revealed a significant correlation between the FEMg and the NAG index (R = 0.60) but not for other parameters. A multivariate regression analysis confirmed the significance of the FEMg as an effective predictor of the NAG index. The FEMg showed a significant correlation with the estimated glomerular filtration rate (eGFR) in the patients with eGFR ≤ 30 mL/min. The correlation of FEMg with the NAG index was not observed in the primary glomerulonephritis patients but was apparent in the patients with hypertensive nephrosclerosis or interstitial nephritis. CONCLUSION: Our findings may indicate that the combination of the FEMg and the NAG index can provide a specific, sensitive assessment for TIN in patients without renal insufficiency.
BACKGROUND: Elevated urine Mg excretion and its correlation with histological damage in tubulo-interstitial nephropathy (TIN) were reported. Here we investigated the clinical significance of the fractional excretion of Mg (FEMg) for the prediction of TIN. METHODS: We enrolled and assessed 94 adult patients with various renal diseases diagnosed principally by renal biopsy. RESULTS: Our stratified analysis based on the value of the conventional TIN parameter N-acetylglucosaminidase (NAG) excretion showed that the high-NAG index group (more than median value of NAG-to-Cr ratio, n = 47) demonstrated significantly high FEMg values (p = 0.017). A univariate analysis revealed a significant correlation between the FEMg and the NAG index (R = 0.60) but not for other parameters. A multivariate regression analysis confirmed the significance of the FEMg as an effective predictor of the NAG index. The FEMg showed a significant correlation with the estimated glomerular filtration rate (eGFR) in the patients with eGFR ≤ 30 mL/min. The correlation of FEMg with the NAG index was not observed in the primary glomerulonephritispatients but was apparent in the patients with hypertensive nephrosclerosis or interstitial nephritis. CONCLUSION: Our findings may indicate that the combination of the FEMg and the NAG index can provide a specific, sensitive assessment for TIN in patients without renal insufficiency.
Authors: P Futrakul; S Yenrudi; N Futrakul; R Sensirivatana; P Kingwatanakul; J Jungthirapanich; T Cherdkiadtikul; A Laohapaibul; D Watana; V Singkhwa; S Futrakul; P Pongsin Journal: Am J Kidney Dis Date: 1999-05 Impact factor: 8.860
Authors: Raimunda Sheyla Carneiro Dias; Dyego José de Araújo Brito; Elisângela Milhomem Dos Santos; Rayanna Cadilhe de Oliveira Costa; Andrea Martins Melo Fontenele; Elane Viana Hortegal Furtado; Joyce Santos Lages; Alcione Miranda Dos Santos; Elton Jonh Freitas Santos; Érika Cristina Ribeiro de Lima Carneiro; Maria Célia Cruz Diniz; Carla Déa Trindade Barbosa; Alessandra Costa de Sales Muniz; Ana Karina Teixeira da Cunha França; Natalino Salgado Filho; Denizar Vianna Araújo; Mário Bernardo-Filho Journal: Int J Nephrol Renovasc Dis Date: 2020-11-19