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Literature DB >> 25723916

ENU mutagenesis in the mouse.

Abstract

This article describes the treatment of laboratory mice with the mutagen N-ethyl-N-nitrosourea (ENU) to induce very highly increased rates of mutation throughout the genome. Further, it describes several popular mating schemes designed to produce animals displaying phenotypes associated with the induced mutations.

Entities: Chemical Species

Keywords: alkylating agent; genome sequencing; per locus mutation frequency; phenotype-driven mutagenesis; spermatogonial stem cells

Mesh：

Substances：
Mutagens
Ethylnitrosourea

Year: 2014 PMID： 25723916 DOI： 10.1002/9780470942390.mo140029

Source DB: PubMed Journal: Curr Protoc Mouse Biol ISSN： 2161-2617

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Cited

6 in total

1. Oxidant stress induction and signalling in xenografted (human breast cancer-tissues) plus estradiol treated or N-ethyl-N-nitrosourea treated female rats via altered estrogen sulfotransferase (rSULT1E1) expressions and SOD1/catalase regulations.

Authors: Aarifa Nazmeen; Smarajit Maiti
Journal: Mol Biol Rep Date: 2018-10-12 Impact factor: 2.316

Review 2. The old and new face of craniofacial research: How animal models inform human craniofacial genetic and clinical data.

Authors: Eric Van Otterloo; Trevor Williams; Kristin Bruk Artinger
Journal: Dev Biol Date: 2016-01-22 Impact factor: 3.582

3. Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice.

Authors: Krista A Geister; Andrew E Timms; David R Beier
Journal: G3 (Bethesda) Date: 2018-02-02 Impact factor: 3.154

ENU mutagenesis in the mouse.

1. Oxidant stress induction and signalling in xenografted (human breast cancer-tissues) plus estradiol treated or N-ethyl-N-nitrosourea treated female rats via altered estrogen sulfotransferase (rSULT1E1) expressions and SOD1/catalase regulations.

Review 2. The old and new face of craniofacial research: How animal models inform human craniofacial genetic and clinical data.

3. Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice.

4. Variant mapping and mutation discovery in inbred mice using next-generation sequencing.

5. Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice.

6. A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.