Literature DB >> 25723256

Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.

Jung-Rae Rho1, Gurusamy Subramaniam2, Hyukjae Choi3, Eun-Hee Kim4, Sok Peng Ng2, K Yoganathan2, Siewbee Ng2, Antony D Buss2, Mark S Butler2, William H Gerwick1,3.   

Abstract

Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database.

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Year:  2015        PMID： 25723256      PMCID： PMC5125438          DOI： 10.1021/acs.orglett.5b00068

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  12 in total

1.  Toward the creation of NMR databases in chiral solvents for assignments of relative and absolute stereochemistry: scope and limitation.

Authors:  N Hayashi; Y Kobayashi; Y Kishi
Journal:  Org Lett       Date:  2001-07-12       Impact factor: 6.005

Review 2.  The bacterial Sec-translocase: structure and mechanism.

Authors:  Jelger A Lycklama A Nijeholt; Arnold J M Driessen
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-04-19       Impact factor: 6.237

3.  Identification of small molecule inhibitors against SecA of Candidatus Liberibacter asiaticus by structure based design.

Authors:  Nagaraju Akula; Pankaj Trivedi; Frank Q Han; Nian Wang
Journal:  Eur J Med Chem       Date:  2012-06-02       Impact factor: 6.514

Review 4.  Determination of relative configuration in organic compounds by NMR spectroscopy and computational methods.

Authors:  Giuseppe Bifulco; Paolo Dambruoso; Luigi Gomez-Paloma; Raffaele Riccio
Journal:  Chem Rev       Date:  2007-07-25       Impact factor: 60.622

5.  Quaternary dynamics of the SecA motor drive translocase catalysis.

Authors:  Giorgos Gouridis; Spyridoula Karamanou; Marios Frantzeskos Sardis; Martin Alexander Schärer; Guido Capitani; Anastassios Economou
Journal:  Mol Cell       Date:  2013-12-12       Impact factor: 17.970

6.  Mathemycin A, a new antifungal macrolactone from Actinomycete sp. HIL Y-8620959. II. Structure elucidation.

Authors:  T Mukhopadhyay; E K Vijayakumar; S R Nadkarni; H W Fehlhaber; H Kogler; S Petry
Journal:  J Antibiot (Tokyo)       Date:  1998-06       Impact factor: 2.649

Review 7.  Traffic jam at the bacterial sec translocase: targeting the SecA nanomotor by small-molecule inhibitors.

Authors:  Kenneth Segers; Jozef Anné
Journal:  Chem Biol       Date:  2011-06-24

Review 8.  Antibiotic targeting of the bacterial secretory pathway.

Authors:  Smitha Rao C V; Evelien De Waelheyns; Anastassios Economou; Jozef Anné
Journal:  Biochim Biophys Acta       Date:  2014-02-15

9.  Design, synthesis and biological evaluation of rose bengal analogues as SecA inhibitors.

Authors:  Jianmei Cui; Jinshan Jin; Ying-Hsin Hsieh; Hsiuchin Yang; Bowen Ke; Krishna Damera; Phang C Tai; Binghe Wang
Journal:  ChemMedChem       Date:  2013-06-21       Impact factor: 3.466

10.  Stereochemical Determination of Acyclic Structures Based on Carbon-Proton Spin-Coupling Constants. A Method of Configuration Analysis for Natural Products.

Authors:  Nobuaki Matsumori; Daisuke Kaneno; Michio Murata; Hideshi Nakamura; Kazuo Tachibana
Journal:  J Org Chem       Date:  1999-02-05       Impact factor: 4.354
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  2 in total

1.  The 160K Natural Organism Library, a unique resource for natural products research.

Authors:  Siew Bee Ng; Yoganathan Kanagasundaram; Hao Fan; Prakash Arumugam; Birgit Eisenhaber; Frank Eisenhaber
Journal:  Nat Biotechnol       Date:  2018-07-06       Impact factor: 54.908

Review 2.  Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs.

Authors:  Hefa Mangzira Kemung; Loh Teng-Hern Tan; Tahir Mehmood Khan; Kok-Gan Chan; Priyia Pusparajah; Bey-Hing Goh; Learn-Han Lee
Journal:  Front Microbiol       Date:  2018-09-24       Impact factor: 5.640
  2 in total

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