Literature DB >> 2572262

The cardiovascular pharmacology of xamoterol, cicloprolol, prenalterol and pindolol in the anaesthetised dog.

S E Hadfield1, S J Slee, H M Snow.   

Abstract

An anaesthetised dog preparation was used to examine the pharmacological profiles of xamoterol, cicloprolol, prenalterol and pindolol. The effects of these agents on heart rate and hind limb perfusion pressure revealed that xamoterol is highly cardioselective and has no significant agonist activity at beta 2-receptors and no membrane stabilising effect. These pharmacological properties are not complicated by the formation of active metabolites and may explain the clinical benefits in the long-term treatment of heart failure.

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Year:  1989        PMID： 2572262      PMCID： PMC1379883          DOI： 10.1111/j.1365-2125.1989.tb03580.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  5 in total

1.  Hemodynamic-inotropic response to beta-blocker with intrinsic sympathomimetic activity in patients with congestive cardiomyopathy.

Authors:  P F Binkley; R F Lewe; J J Lima; A Al-Awwa; D V Unverferth; C V Leier
Journal:  Circulation       Date:  1986-12       Impact factor: 29.690

2.  Long-term hemodynamic effects of prenalterol in patients with severe congestive heart failure.

Authors:  H Lambertz; J Meyer; R Erbel
Journal:  Circulation       Date:  1984-02       Impact factor: 29.690

3.  The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551).

Authors:  A J Bilski; S E Halliday; J D Fitzgerald; J L Wale
Journal:  J Cardiovasc Pharmacol       Date:  1983 May-Jun       Impact factor: 3.105

4.  The cardiovascular effects of ICI 118,587: A beta 1-adrenoceptor partial agonist.

Authors:  A Nuttall; H M Snow
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

5.  Acute intravenous and sustained oral treatment with the beta1 agonist prenalterol in patients with chronic severe cardiac failure.

Authors:  P J Currie; M J Kelly; K Middlebrook; J Federman; E Sainsbury; J Ashley; A Pitt
Journal:  Br Heart J       Date:  1984-05
  5 in total
  1 in total

1.  Evaluation of the effect on heart rate variability of a beta2-adrenoceptor agonist and antagonist using non-linear scatterplot and sequence methods.

Authors:  C G Hanratty; B Silke; J G Riddell
Journal:  Br J Clin Pharmacol       Date:  1999-02       Impact factor: 4.335
  1 in total

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