Jeam Haroldo Oliveira Barbosa1, Antonio Carlos Santos2, Vitor Tumas2, Manju Liu3, Weili Zheng3, E Mark Haacke4, Carlos Ernesto Garrido Salmon5. 1. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address: jeamharoldo@hotmail.com. 2. Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. 3. MRI Institute for Biomedical Research, Detroit, MI, United States. 4. MRI Institute for Biomedical Research, Detroit, MI, United States; Wayne State University, Detroit, MI, United States. 5. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Abstract
PURPOSE: To evaluate the sensitivity and specificity of quantitative magnetic resonance (MR) iron mapping including R2, R2* and magnetic susceptibility to differentiate patients with Parkinson's disease (PD) from healthy controls. MATERIALS AND METHODS: Thirty (30) healthy controls (HC) (64±7years old) and 20 patients with idiopathic PD (66±8years old) were studied using a 3T MR imaging scanner. R2 maps were generated from GRASE sequence while R2*, and quantitative susceptibility mapping (QSM) were obtained from a conventional multi-echo gradient-echo sequence. R2, R2* and relative susceptibility (Δχ) values of structures in the basal ganglia were measured for each patient and control. An analysis of sensitivity and specificity and unpaired t-test was applied to the two groups. RESULTS: A significant difference (p<0.05) was found for R2 and ∆χ values in the substantia nigra as a whole and in the pars compacta for PD patients. The R2* values were different significantly (p<0.05) only on the substantia nigra pars compacta. QSM presented the highest sensitivity and specificity to differentiate the two populations. CONCLUSION: The QSM map was the most sensitive quantitative technique for detecting a significant increase of iron for PD. The highest significant difference between controls and patients was found in the substantia nigra pars compacta using QSM.
PURPOSE: To evaluate the sensitivity and specificity of quantitative magnetic resonance (MR) iron mapping including R2, R2* and magnetic susceptibility to differentiate patients with Parkinson's disease (PD) from healthy controls. MATERIALS AND METHODS: Thirty (30) healthy controls (HC) (64±7years old) and 20 patients with idiopathic PD (66±8years old) were studied using a 3T MR imaging scanner. R2 maps were generated from GRASE sequence while R2*, and quantitative susceptibility mapping (QSM) were obtained from a conventional multi-echo gradient-echo sequence. R2, R2* and relative susceptibility (Δχ) values of structures in the basal ganglia were measured for each patient and control. An analysis of sensitivity and specificity and unpaired t-test was applied to the two groups. RESULTS: A significant difference (p<0.05) was found for R2 and ∆χ values in the substantia nigra as a whole and in the pars compacta for PDpatients. The R2* values were different significantly (p<0.05) only on the substantia nigra pars compacta. QSM presented the highest sensitivity and specificity to differentiate the two populations. CONCLUSION: The QSM map was the most sensitive quantitative technique for detecting a significant increase of iron for PD. The highest significant difference between controls and patients was found in the substantia nigra pars compacta using QSM.
Authors: Michael Iv; Peyman Samghabadi; Samantha Holdsworth; Andrew Gentles; Paymon Rezaii; Griffith Harsh; Gordon Li; Reena Thomas; Michael Moseley; Heike E Daldrup-Link; Hannes Vogel; Max Wintermark; Samuel Cheshier; Kristen W Yeom Journal: Radiology Date: 2018-11-06 Impact factor: 11.105
Authors: Mechelle M Lewis; Guangwei Du; Jennifer Baccon; Amanda M Snyder; Ben Murie; Felicia Cooper; Christy Stetter; Lan Kong; Christopher Sica; Richard B Mailman; James R Connor; Xuemei Huang Journal: Mov Disord Date: 2018-05-14 Impact factor: 10.338