| Literature DB >> 25721261 |
Josep M Casacuberta1, Yann Devos2, Patrick du Jardin3, Matthew Ramon2, Hervé Vaucheret4, Fabien Nogué5.
Abstract
RNAi offers opportunities to generate new traits in genetically modified (GM) plants. Instead of expressing novel proteins, RNAi-based GM plants reduce target gene expression. Silencing of off-target genes may trigger unintended effects, and identifying these genes would facilitate risk assessment. However, using bioinformatics alone is not reliable, due to the lack of genomic data and insufficient knowledge of mechanisms governing mRNA-small (s)RNA interactions.Keywords: food/feed safety; gene silencing; genetically modified organism (GMO); nontarget organism (NTO); off-target gene; plant breeding.
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Year: 2015 PMID： 25721261 DOI： 10.1016/j.tibtech.2014.12.003
Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536