Literature DB >> 25720962

Huntingtin facilitates selective autophagy.

Amir Gelman1, Moran Rawet-Slobodkin1, Zvulun Elazar1.   

Abstract

Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.

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Year:  2015        PMID： 25720962     DOI： 10.1038/ncb3125

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  14 in total

1.  Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain.

Authors:  Alexandre Kuhn; Doris Thu; Henry J Waldvogel; Richard L M Faull; Ruth Luthi-Carter
Journal:  Nat Methods       Date:  2011-10-09       Impact factor: 28.547

2.  Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin.

Authors:  Dale D O Martin; Ryan J Heit; Megan C Yap; Michael W Davidson; Michael R Hayden; Luc G Berthiaume
Journal:  Hum Mol Genet       Date:  2014-01-23       Impact factor: 6.150

Review 3.  Getting ready for building: signaling and autophagosome biogenesis.

Authors:  Adi Abada; Zvulun Elazar
Journal:  EMBO Rep       Date:  2014-07-15       Impact factor: 8.807

4.  The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.

Authors:  Yvette C Wong; Erika L F Holzbaur
Journal:  J Neurosci       Date:  2014-01-22       Impact factor: 6.167

5.  Potential function for the Huntingtin protein as a scaffold for selective autophagy.

Authors:  Joseph Ochaba; Tamás Lukacsovich; George Csikos; Shuqiu Zheng; Julia Margulis; Lisa Salazar; Kai Mao; Alice L Lau; Sylvia Y Yeung; Sandrine Humbert; Frédéric Saudou; Daniel J Klionsky; Steven Finkbeiner; Scott O Zeitlin; J Lawrence Marsh; David E Housman; Leslie M Thompson; Joan S Steffan
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-10       Impact factor: 11.205

Review 6.  Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.

Authors:  Vladimir Rogov; Volker Dötsch; Terje Johansen; Vladimir Kirkin
Journal:  Mol Cell       Date:  2014-01-23       Impact factor: 17.970

7.  Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.

Authors:  Marta Martinez-Vicente; Zsolt Talloczy; Esther Wong; Guomei Tang; Hiroshi Koga; Susmita Kaushik; Rosa de Vries; Esperanza Arias; Spike Harris; David Sulzer; Ana Maria Cuervo
Journal:  Nat Neurosci       Date:  2010-04-11       Impact factor: 24.884

Review 8.  Autophagy in Huntington disease and huntingtin in autophagy.

Authors:  Dale D O Martin; Safia Ladha; Dagmar E Ehrnhoefer; Michael R Hayden
Journal:  Trends Neurosci       Date:  2014-10-02       Impact factor: 13.837

Review 9.  Normal huntingtin function: an alternative approach to Huntington's disease.

Authors:  Elena Cattaneo; Chiara Zuccato; Marzia Tartari
Journal:  Nat Rev Neurosci       Date:  2005-12       Impact factor: 34.870

10.  Huntingtin functions as a scaffold for selective macroautophagy.

Authors:  Yan-Ning Rui; Zhen Xu; Bindi Patel; Zhihua Chen; Dongsheng Chen; Antonio Tito; Gabriela David; Yamin Sun; Erin F Stimming; Hugo J Bellen; Ana Maria Cuervo; Sheng Zhang
Journal:  Nat Cell Biol       Date:  2015-02-16       Impact factor: 28.824
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  10 in total

Review 1.  The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease.

Authors:  David Blum; Yijuang Chern; Maria Rosaria Domenici; Luc Buée; Chien-Yu Lin; William Rea; Sergi Ferré; Patrizia Popoli
Journal:  J Caffeine Adenosine Res       Date:  2018-06-01

2.  Acute manganese treatment restores defective autophagic cargo loading in Huntington's disease cell lines.

Authors:  Miles R Bryan; Michael T O'Brien; Kristen D Nordham; Daniel I R Rose; Audra M Foshage; Piyush Joshi; Rachana Nitin; Michael A Uhouse; Alba Di Pardo; Ziyan Zhang; Vittorio Maglione; Michael Aschner; Aaron B Bowman
Journal:  Hum Mol Genet       Date:  2019-11-15       Impact factor: 6.150

3.  Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms.

Authors:  Meixin Tao; Nitin K Pandey; Ryan Barnes; Songi Han; Ralf Langen
Journal:  Structure       Date:  2019-08-26       Impact factor: 5.006

Review 4.  A role for autophagy in Huntington's disease.

Authors:  Katherine R Croce; Ai Yamamoto
Journal:  Neurobiol Dis       Date:  2018-08-24       Impact factor: 5.996

Review 5.  Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.

Authors:  Miles R Bryan; Aaron B Bowman
Journal:  Adv Neurobiol       Date:  2017

6.  p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.

Authors:  Hyunjoo Cha-Molstad; Ji Eun Yu; Zhiwei Feng; Su Hyun Lee; Jung Gi Kim; Peng Yang; Bitnara Han; Ki Woon Sung; Young Dong Yoo; Joonsung Hwang; Terry McGuire; Sang Mi Shim; Hyun Dong Song; Srinivasrao Ganipisetti; Nuozhou Wang; Jun Min Jang; Min Jae Lee; Seung Jun Kim; Kyung Ho Lee; Jin Tae Hong; Aaron Ciechanover; Inhee Mook-Jung; Kwang Pyo Kim; Xiang-Qun Xie; Yong Tae Kwon; Bo Yeon Kim
Journal:  Nat Commun       Date:  2017-07-24       Impact factor: 14.919

7.  Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes.

Authors:  Xuezhao Liu; Limin Yin; Tianyou Li; Lingxi Lin; Jie Zhang; Yang Li
Journal:  PLoS Genet       Date:  2021-03-17       Impact factor: 5.917

Review 8.  Non-Cell Autonomous and Epigenetic Mechanisms of Huntington's Disease.

Authors:  Chaebin Kim; Ali Yousefian-Jazi; Seung-Hye Choi; Inyoung Chang; Junghee Lee; Hoon Ryu
Journal:  Int J Mol Sci       Date:  2021-11-19       Impact factor: 5.923

Review 9.  Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions.

Authors:  Waleska Kerllen Martins; Maryana do Nascimento da Silva; Kiran Pandey; Ikuko Maejima; Ercília Ramalho; Vania Claudia Olivon; Susana Nogueira Diniz; Daniel Grasso
Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-06-01

Review 10.  The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases.

Authors:  Sina Shadfar; Mariana Brocardo; Julie D Atkin
Journal:  Int J Mol Sci       Date:  2022-02-24       Impact factor: 5.923
  10 in total

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