Literature DB >> 25720961

Merlin's wizardry guides cohesive migration.

Ansgar Zoch1, Helen Morrison1.   

Abstract

Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin-Rich1 complex and the Rac1 small GTPase.

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Year:  2015        PMID： 25720961     DOI： 10.1038/ncb3126

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  12 in total

1.  The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.

Authors:  Andrew B Gladden; Alan M Hebert; Eveline E Schneeberger; Andrea I McClatchey
Journal:  Dev Cell       Date:  2010-11-16       Impact factor: 12.270

Review 2.  Collective cell migration: a mechanistic perspective.

Authors:  Sri Ram Krishna Vedula; Andrea Ravasio; Chwee Teck Lim; Benoit Ladoux
Journal:  Physiology (Bethesda)       Date:  2013-11

3.  Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors.

Authors:  A I McClatchey; I Saotome; K Mercer; D Crowley; J F Gusella; R T Bronson; T Jacks
Journal:  Genes Dev       Date:  1998-04-15       Impact factor: 11.361

4.  The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.

Authors:  A I McClatchey; I Saotome; V Ramesh; J F Gusella; T Jacks
Journal:  Genes Dev       Date:  1997-05-15       Impact factor: 11.361

5.  Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase.

Authors:  Hongchuan Jin; Tobias Sperka; Peter Herrlich; Helen Morrison
Journal:  Nature       Date:  2006-08-03       Impact factor: 49.962

6.  A molecular mechanotransduction pathway regulates collective migration of epithelial cells.

Authors:  Tamal Das; Kai Safferling; Sebastian Rausch; Niels Grabe; Heike Boehm; Joachim P Spatz
Journal:  Nat Cell Biol       Date:  2015-02-23       Impact factor: 28.824

7.  Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac.

Authors:  Helen Morrison; Tobias Sperka; Jan Manent; Marco Giovannini; Helmut Ponta; Peter Herrlich
Journal:  Cancer Res       Date:  2007-01-15       Impact factor: 12.701

8.  The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion.

Authors:  Margaret E McLaughlin; Genevieve M Kruger; Kelly L Slocum; Denise Crowley; Norman A Michaud; Jennifer Huang; Margaret Magendantz; Tyler Jacks
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-20       Impact factor: 11.205

9.  Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K.

Authors:  Naoya Yamaguchi; Takeomi Mizutani; Kazushige Kawabata; Hisashi Haga
Journal:  Sci Rep       Date:  2015-01-07       Impact factor: 4.379

10.  Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.

Authors:  Feng Yin; Jianzhong Yu; Yonggang Zheng; Qian Chen; Nailing Zhang; Duojia Pan
Journal:  Cell       Date:  2013-09-05       Impact factor: 41.582
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  1 in total

Review 1.  Roles of leader and follower cells in collective cell migration.

Authors:  Lei Qin; Dazhi Yang; Weihong Yi; Huiling Cao; Guozhi Xiao
Journal:  Mol Biol Cell       Date:  2021-07-01       Impact factor: 4.138
  1 in total

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