BACKGROUND: The field of quantifying the association between the intake of vitamin C and risk of glioma still has conflicts. Thus, we performed a comprehensive meta-analysis to test the hypothesis that a high intake of vitamin C may be a protective effect on glioma risk. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to June 2014. The random-effect model was used to combine study-specific results. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test. RESULTS: Thirteen articles with 15 studies (2 cohort study and 13 case-control studies) involving 3,409 glioma cases about vitamin C intake and glioma risk were used in this meta-analysis. The combined relative risks (RRs) of glioma associated with vitamin C intake was 0.86 (95% CIs = 0.75-0.99). Overall, significant protective associations were also found in the American population (RRs = 0.85, 95% CIs = 0.73-0.98) and case-control studies (RRs = 0.80, 95% CIs = 0.69-0.93). No publication bias was found. CONCLUSIONS: Our analysis indicated that vitamin C intake might decrease the risk of glioma, especially among the Americans.
BACKGROUND: The field of quantifying the association between the intake of vitamin C and risk of glioma still has conflicts. Thus, we performed a comprehensive meta-analysis to test the hypothesis that a high intake of vitamin C may be a protective effect on glioma risk. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to June 2014. The random-effect model was used to combine study-specific results. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test. RESULTS: Thirteen articles with 15 studies (2 cohort study and 13 case-control studies) involving 3,409 glioma cases about vitamin C intake and glioma risk were used in this meta-analysis. The combined relative risks (RRs) of glioma associated with vitamin C intake was 0.86 (95% CIs = 0.75-0.99). Overall, significant protective associations were also found in the American population (RRs = 0.85, 95% CIs = 0.73-0.98) and case-control studies (RRs = 0.80, 95% CIs = 0.69-0.93). No publication bias was found. CONCLUSIONS: Our analysis indicated that vitamin C intake might decrease the risk of glioma, especially among the Americans.
Authors: A E Howell; J W Robinson; R E Wootton; A McAleenan; S Tsavachidis; Q T Ostrom; M Bondy; G Armstrong; C Relton; P Haycock; R M Martin; J Zheng; K M Kurian Journal: BMC Cancer Date: 2020-06-03 Impact factor: 4.430
Authors: Amy Elizabeth Howell; Jie Zheng; Philip C Haycock; Alexandra McAleenan; Caroline Relton; Richard M Martin; Kathreena M Kurian Journal: Front Genet Date: 2018-11-12 Impact factor: 4.599