| Literature DB >> 25720818 |
Zhengzan Zhang1, Guilan Quan1, Qiaoli Wu1, Chan Zhou2, Feng Li2, Xuequn Bai1, Ge Li3, Xin Pan1, Chuanbin Wu4.
Abstract
The aim of this study was to load amorphous hydrophobic drug into ordered mesoporous silica (SBA-15) by supercritical carbon dioxide technology in order to improve the dissolution and bioavailability of the drug. Asarone was selected as a model drug due to its lipophilic character and poor bioavailability. In vitro dissolution and in vivo bioavailability of the obtained Asarone-SBA-15 were significantly improved as compared to the micronized crystalline drug. This study offers an effective, safe, and environmentally benign means of solving the problems relating to the solubility and bioavailability of hydrophobic molecules.Entities:
Keywords: Amorphous; Bioavailability; Dissolution; Hydrophobic molecules; Mesoporous silica; Supercritical carbon dioxide
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Year: 2015 PMID： 25720818 DOI： 10.1016/j.ejpb.2015.02.018
Source DB: PubMed Journal: Eur J Pharm Biopharm ISSN： 0939-6411 Impact factor: 5.571