Yan-Yan Hu1, Gui-Mei Li, Wei Wang. 1. Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China. E-mail. hyanyansmile@hotmail.com.
Abstract
OBJECTIVES: To investigate characteristics of euthyroid sick syndrome (ESS) in children with diabetic ketoacidosis (DKA). METHODS: This retrospective study was carried out between May 2010 and April 2013 at the Pediatric Department of Shandong Provincial Hospital, Shandong University, Shandong, China. Diabetic ketoacidosis children were divided into 2 groups: euthyroidism (group one, n=30) and ESS (group 2, n=40). C-peptide, glycosylated hemoglobin (HbA1c), bicarbonate, anion gap (AG), free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) levels were measured before and after 7 days of insulin treatment. Daily blood glucose (BG) profiles were recorded. RESULTS: Glycosylated hemoglobin, AG, the mean daily BG, and fasting blood glucose levels were higher, and bicarbonate, FT3, FT4, and TSH levels were lower in group 2 than in group one (all p<0.05). Free triiodothyronine (r=-0.593, p<0.001) and FT4 (r=-0.402, p=0.001) were negatively correlated with HbA1c. Free triiodothyronine (r=-0.438, p<0.001) and FT4 (r=-0.505, p<0.001) were negatively correlated with AG, and FT3 (r=0.503, p<0.001) and FT4 (r=0.448, p<0.001) were positively correlated with bicarbonate. CONCLUSION: Diabetic ketoacidosis children with ESS have poor diabetic control. Free thyroid hormones are associated with the severity of DKA.
OBJECTIVES: To investigate characteristics of euthyroid sick syndrome (ESS) in children with diabetic ketoacidosis (DKA). METHODS: This retrospective study was carried out between May 2010 and April 2013 at the Pediatric Department of Shandong Provincial Hospital, Shandong University, Shandong, China. Diabetic ketoacidosischildren were divided into 2 groups: euthyroidism (group one, n=30) and ESS (group 2, n=40). C-peptide, glycosylated hemoglobin (HbA1c), bicarbonate, anion gap (AG), free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) levels were measured before and after 7 days of insulin treatment. Daily blood glucose (BG) profiles were recorded. RESULTS: Glycosylated hemoglobin, AG, the mean daily BG, and fasting blood glucose levels were higher, and bicarbonate, FT3, FT4, and TSH levels were lower in group 2 than in group one (all p&lt;0.05). Free triiodothyronine (r=-0.593, p&lt;0.001) and FT4 (r=-0.402, p=0.001) were negatively correlated with HbA1c. Free triiodothyronine (r=-0.438, p&lt;0.001) and FT4 (r=-0.505, p&lt;0.001) were negatively correlated with AG, and FT3 (r=0.503, p&lt;0.001) and FT4 (r=0.448, p&lt;0.001) were positively correlated with bicarbonate. CONCLUSION:Diabetic ketoacidosischildren with ESS have poor diabetic control. Free thyroid hormones are associated with the severity of DKA.
Authors: Sang Heon Song; Ihm Soo Kwak; Dong Won Lee; Yang Ho Kang; Eun Young Seong; Jin Sup Park Journal: Nephrol Dial Transplant Date: 2008-12-23 Impact factor: 5.992
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