OBJECTIVE: To assess the relationships between components of the growth hormone axis, body composition, and bone markers in obese children. METHODS: We determined the levels of bone alkaline phosphatase (BALP), C-terminal telopeptide of type I collagen (CTX-I), insulin-like growth factor-I (IGF-I), and IGF-binding proteins (IGFBPs) by immunoenzymatic methods, and body composition by dual-energy X-ray absorptiometry in 45 obese and 20 non-obese children. RESULTS: IGF-I and functional IGFBP-3 levels, IGF-I/total IGFBP-3, and functional IGFBP-3/total IGFBP-3 molar ratios were significantly higher in obese patients than in controls. Multivariate regression analysis in obese patients showed significant associations of BALP with IGF-I (p=0.047) and percent of body fat mass (p=0.002). CONCLUSION: The relationship of IGF-I and functional IGFBP-3 to BALP may support the concept of IGF-I influence on accelerated bone formation process in obesity. Moreover, IGF-I and percentage of body fat mass may be significant predictors of BALP in obese during the prepubertal period.
OBJECTIVE: To assess the relationships between components of the growth hormone axis, body composition, and bone markers in obesechildren. METHODS: We determined the levels of bone alkaline phosphatase (BALP), C-terminal telopeptide of type I collagen (CTX-I), insulin-like growth factor-I (IGF-I), and IGF-binding proteins (IGFBPs) by immunoenzymatic methods, and body composition by dual-energy X-ray absorptiometry in 45 obese and 20 non-obesechildren. RESULTS:IGF-I and functional IGFBP-3 levels, IGF-I/total IGFBP-3, and functional IGFBP-3/total IGFBP-3 molar ratios were significantly higher in obesepatients than in controls. Multivariate regression analysis in obesepatients showed significant associations of BALP with IGF-I (p=0.047) and percent of body fat mass (p=0.002). CONCLUSION: The relationship of IGF-I and functional IGFBP-3 to BALP may support the concept of IGF-I influence on accelerated bone formation process in obesity. Moreover, IGF-I and percentage of body fat mass may be significant predictors of BALP in obese during the prepubertal period.
Authors: David E Maridas; Victoria E DeMambro; Phuong T Le; Subburaman Mohan; Clifford J Rosen Journal: Endocrinology Date: 2017-10-01 Impact factor: 4.736
Authors: Marianna Beghini; Stephanie Brandt; Ingrid Körber; Katja Kohlsdorf; Heike Vollbach; Belinda Lennerz; Christian Denzer; Shlomit Shalitin; Ferruccio Santini; Werner F Blum; Julia von Schnurbein; Martin Wabitsch Journal: Int J Obes (Lond) Date: 2021-05-17 Impact factor: 5.095