| Literature DB >> 25716905 |
Hugh Y Zhu1, Jagdish Desai1, Yongqi Deng2, Alan Cooper1, James Wang1, Jerry Shipps2, Ahmed Samatar3, Donna Carr3, William Windsor3.
Abstract
Starting from weak μM hits identified through affinity based Automated Ligand Identification System (ALIS) screenings, double digit nM hydroxyaniline amide Erk inhibitors were discovered. This class of compounds had the unique dual mechanism of inhibiting activated and non-activated forms of Erk. They generally had high degree of selectivity in kinase panel tested.Entities:
Keywords: ALIS; Erk; Extracellular regulated kinase; MAPK; NeoMorph
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Year: 2015 PMID： 25716905 DOI： 10.1016/j.bmcl.2015.01.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823