Literature DB >> 25716857

Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.

Scott Ayton1, Peng Lei1, Dominic J Hare2, James A Duce3, Jessica L George1, Paul A Adlard1, Catriona McLean4, Jack T Rogers5, Robert A Cherny1, David I Finkelstein1, Ashley I Bush6.   

Abstract

Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated with Parkinson's disease (PD) pathogenesis. We reported previously that the Alzheimer-associated β-amyloid precursor protein (APP) facilitates neuronal iron export. Here we report markedly decreased APP expression in dopaminergic neurons of human PD nigra and that APP(-/-) mice develop iron-dependent nigral cell loss. Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD.
Copyright © 2015 the authors 0270-6474/15/353591-07$15.00/0.

Entities:  

Keywords:  APP; iron; nitric oxide

Mesh：

Substances：

Year:  2015        PMID： 25716857      PMCID： PMC6605561          DOI： 10.1523/JNEUROSCI.3439-14.2015

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  21 in total

1.  Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

Authors:  Peng Lei; Scott Ayton; David I Finkelstein; Loredana Spoerri; Giuseppe D Ciccotosto; David K Wright; Bruce X W Wong; Paul A Adlard; Robert A Cherny; Linh Q Lam; Blaine R Roberts; Irene Volitakis; Gary F Egan; Catriona A McLean; Roberto Cappai; James A Duce; Ashley I Bush
Journal:  Nat Med       Date:  2012-01-29       Impact factor: 53.440

2.  Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels.

Authors:  J A Duce; S Ayton; A A Miller; A Tsatsanis; L Q Lam; L Leone; J E Corbin; H Butzkueven; T J Kilpatrick; J T Rogers; K J Barnham; D I Finkelstein; A I Bush
Journal:  Mol Psychiatry       Date:  2012-01-03       Impact factor: 15.992

3.  Endothelial nitric oxide modulates expression and processing of amyloid precursor protein.

Authors:  Susan A Austin; Anantha V Santhanam; Zvonimir S Katusic
Journal:  Circ Res       Date:  2010-12-02       Impact factor: 17.367

4.  Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.

Authors:  James A Duce; Andrew Tsatsanis; Michael A Cater; Simon A James; Elysia Robb; Krutika Wikhe; Su Ling Leong; Keyla Perez; Timothy Johanssen; Mark A Greenough; Hyun-Hee Cho; Denise Galatis; Robert D Moir; Colin L Masters; Catriona McLean; Rudolph E Tanzi; Roberto Cappai; Kevin J Barnham; Giuseppe D Ciccotosto; Jack T Rogers; Ashley I Bush
Journal:  Cell       Date:  2010-09-17       Impact factor: 41.582

5.  Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.

Authors:  Scott Ayton; Peng Lei; James A Duce; Bruce X W Wong; Amelia Sedjahtera; Paul A Adlard; Ashley I Bush; David I Finkelstein
Journal:  Ann Neurol       Date:  2013-02-19       Impact factor: 10.422

6.  Early locus coeruleus degeneration and olfactory dysfunctions in Tg2576 mice.

Authors:  Delphine Guérin; Joëlle Sacquet; Nathalie Mandairon; François Jourdan; Anne Didier
Journal:  Neurobiol Aging       Date:  2007-07-05       Impact factor: 4.673

7.  Individual dopaminergic neurons show raised iron levels in Parkinson disease.

Authors:  A E Oakley; J F Collingwood; J Dobson; G Love; H R Perrott; J A Edwardson; M Elstner; C M Morris
Journal:  Neurology       Date:  2007-05-22       Impact factor: 9.910

8.  Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease.

Authors:  Julio Salazar; Natalia Mena; Stephane Hunot; Annick Prigent; Daniel Alvarez-Fischer; Miguel Arredondo; Charles Duyckaerts; Veronique Sazdovitch; Lin Zhao; Laura M Garrick; Marco T Nuñez; Michael D Garrick; Rita Raisman-Vozari; Etienne C Hirsch
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-14       Impact factor: 11.205

9.  An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript.

Authors:  Jack T Rogers; Jeffrey D Randall; Catherine M Cahill; Paul S Eder; Xudong Huang; Hiromi Gunshin; Lorene Leiter; Jay McPhee; Satinder S Sarang; Tada Utsuki; Nigel H Greig; Debomoy K Lahiri; Rudolph E Tanzi; Ashley I Bush; Tony Giordano; Steve R Gullans
Journal:  J Biol Chem       Date:  2002-08-26       Impact factor: 5.157

10.  The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.

Authors:  Lin W Hung; Victor L Villemagne; Lesley Cheng; Nicki A Sherratt; Scott Ayton; Anthony R White; Peter J Crouch; SinChun Lim; Su Ling Leong; Simon Wilkins; Jessica George; Blaine R Roberts; Chi L L Pham; Xiang Liu; Francis C K Chiu; David M Shackleford; Andrew K Powell; Colin L Masters; Ashley I Bush; Graeme O'Keefe; Janetta G Culvenor; Roberto Cappai; Robert A Cherny; Paul S Donnelly; Andrew F Hill; David I Finkelstein; Kevin J Barnham
Journal:  J Exp Med       Date:  2012-04-02       Impact factor: 14.307
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  39 in total

1.  Metalloneurochemistry and the Pierian Spring: 'Shallow Draughts Intoxicate the Brain'.

Authors:  Jacob M Goldberg; Andrei Loas; Stephen J Lippard
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Review 2.  Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease.

Authors:  M Isabel G Lopez Sanchez; Peter van Wijngaarden; Ian A Trounce
Journal:  Br J Pharmacol       Date:  2018-12-18       Impact factor: 8.739

Review 3.  Treating Alzheimer's disease by targeting iron.

Authors:  Sara Nikseresht; Ashley I Bush; Scott Ayton
Journal:  Br J Pharmacol       Date:  2019-02-11       Impact factor: 8.739

4.  Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.

Authors:  Vivek Venkataramani; Thorsten R Doeppner; Desiree Willkommen; Catherine M Cahill; Yongjuan Xin; Guilin Ye; Yanyan Liu; Adam Southon; Allegra Aron; Ho Yu Au-Yeung; Xudong Huang; Debomoy K Lahiri; Fudi Wang; Ashley I Bush; Gerald G Wulf; Philipp Ströbel; Bernhard Michalke; Jack T Rogers
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Review 5.  The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update.

Authors:  Laura Mahoney-Sanchez; Abdel Ali Belaidi; Ashley I Bush; Scott Ayton
Journal:  J Mol Neurosci       Date:  2016-09-19       Impact factor: 3.444

6.  The neuroprotective effects of hydro-alcoholic extract of olive (Olea europaea L.) leaf on rotenone-induced Parkinson's disease in rat.

Authors:  Maryam Sarbishegi; Enam Alhagh Charkhat Gorgich; Ozra Khajavi; Gholamreza Komeili; Saeedeh Salimi
Journal:  Metab Brain Dis       Date:  2017-10-16       Impact factor: 3.584

Review 7.  Conservative iron chelation for neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis.

Authors:  David Devos; Z Ioav Cabantchik; Caroline Moreau; Véronique Danel; Laura Mahoney-Sanchez; Hind Bouchaoui; Flore Gouel; Anne-Sophie Rolland; James A Duce; Jean-Christophe Devedjian
Journal:  J Neural Transm (Vienna)       Date:  2020-01-07       Impact factor: 3.575

8.  Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice.

Authors:  Abdel A Belaidi; Adam P Gunn; Bruce X Wong; Scott Ayton; Ambili T Appukuttan; Blaine R Roberts; James A Duce; Ashley I Bush
Journal:  Neurotherapeutics       Date:  2018-10       Impact factor: 7.620

Review 9.  Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders.

Authors:  Jia-Rui Wu; Qing-Zhang Tuo; Peng Lei
Journal:  J Mol Neurosci       Date:  2018-08-25       Impact factor: 3.444

Review 10.  Brain Iron Metabolism Dysfunction in Parkinson's Disease.

Authors:  Hong Jiang; Jun Wang; Jack Rogers; Junxia Xie
Journal:  Mol Neurobiol       Date:  2016-04-02       Impact factor: 5.590
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