Literature DB >> 25716832

GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding.

Zhaofei Wu1, Eun Ran Kim1, Hao Sun1, Yuanzhong Xu1, Leandra R Mangieri2, De-Pei Li3, Hui-Lin Pan3, Yong Xu4, Benjamin R Arenkiel5, Qingchun Tong6.   

Abstract

Lesions of the lateral hypothalamus (LH) cause hypophagia. However, activation of glutamatergic neurons in LH inhibits feeding. These results suggest a potential importance for other LH neurons in stimulating feeding. Our current study in mice showed that disruption of GABA release from adult LH GABAergic neurons reduced feeding. LH GABAergic neurons project extensively to the paraventricular hypothalamic nucleus (PVH), and optogenetic stimulation of GABAergic LH → PVH fibers induced monosynaptic IPSCs in PVH neurons, and potently increased feeding, which depended on GABA release. In addition, disruption of GABA-A receptors in the PVH reduced feeding. Thus, we have identified a new feeding pathway in which GABAergic projections from the LH to the PVH promote feeding.
Copyright © 2015 the authors 0270-6474/15/353312-07$15.00/0.

Entities:  

Keywords:  GABA; LH; PVH; feeding; optogenetics

Mesh：

Year:  2015        PMID： 25716832      PMCID： PMC4339348          DOI： 10.1523/JNEUROSCI.3720-14.2015

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


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