Jimin Kahng1, Tae Kwan Kim2, Eun Yong Chung2, Yee Suk Kim3, Jeong Yeon Moon2. 1. Department of Laboratory Medicine, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, Republic of Korea. 2. Department of Anaesthesia and Pain Medicine, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, Republic of Korea. 3. Department of Anaesthesia and Pain Medicine, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, Republic of Korea knabi_2000@naver.com.
Abstract
OBJECTIVE: To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats. METHODS: Neuropathy was induced in Sprague-Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180 min after treatment. RESULTS: Mechanical and cold allodynia were reduced by thioctic acid injection. The duration of effect increased with thioctic acid dose. CONCLUSION: Thioctic acid may be an effective treatment for vincristine-induced neuropathy.
OBJECTIVE: To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats. METHODS:Neuropathy was induced in Sprague-Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180 min after treatment. RESULTS: Mechanical and cold allodynia were reduced by thioctic acid injection. The duration of effect increased with thioctic acid dose. CONCLUSION:Thioctic acid may be an effective treatment for vincristine-induced neuropathy.
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